| Literature DB >> 24338350 |
Jurgen R Piet1, Madelijn Geldhoff, Barbera D C van Schaik, Matthijs C Brouwer, Mercedes Valls Seron, Marja E Jakobs, Kim Schipper, Yvonne Pannekoek, Aeilko H Zwinderman, Tom van der Poll, Antoine H C van Kampen, Frank Baas, Arie van der Ende, Diederik van de Beek.
Abstract
Streptococcus pneumoniae (pneumococcus) is a major human pathogen causing pneumonia, sepsis and bacterial meningitis. Using a clinical phenotype based approach with bacterial whole-genome sequencing we identified pneumococcal arginine biosynthesis genes to be associated with outcome in patients with pneumococcal meningitis. Pneumococci harboring these genes show increased growth in human blood and cerebrospinal fluid (CSF). Mouse models of meningitis and pneumonia showed that pneumococcal strains without arginine biosynthesis genes were attenuated in growth or cleared, from lung, blood and CSF. Thus, S. pneumoniae arginine synthesis genes promote growth and virulence in invasive pneumococcal disease.Entities:
Keywords: Streptococcus pneumoniae; arginine synthesis; bacterial meningitis; virulence; whole genome sequencing
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Year: 2013 PMID： 24338350 DOI： 10.1093/infdis/jit818
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226