Literature DB >> 24337667

ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke.

Amadeus Gladbach1, Janet van Eersel, Mian Bi, Yazi D Ke, Lars M Ittner.   

Abstract

Ischemic stroke is a leading cause of death. It has previously been shown that blocking activation of extracellular signal-regulated kinase (ERK) with the MEK inhibitor U0126 mitigates brain damage in rodent models of ischemic stroke. Here we show that the newer MEK inhibitor PD184161 reduces cell death and altered gene expression in cultured neurons and mice undergoing excitotoxicity, and has similar protective effects in a mouse model of stroke. This further supports ERK inhibition as a potential treatment for stroke.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 24337667     DOI： 10.1007/s00702-013-1138-2

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  16 in total

1.  Primary support cultures of hippocampal and substantia nigra neurons.

Authors:  Thomas Fath; Yazi D Ke; Peter Gunning; Jürgen Götz; Lars M Ittner
Journal:  Nat Protoc       Date:  2009       Impact factor: 13.491

2.  MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia.

Authors:  A Alessandrini; S Namura; M A Moskowitz; J V Bonventre
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

3.  Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.

Authors:  Lars M Ittner; Yazi D Ke; Fabien Delerue; Mian Bi; Amadeus Gladbach; Janet van Eersel; Heidrun Wölfing; Billy C Chieng; MacDonald J Christie; Ian A Napier; Anne Eckert; Matthias Staufenbiel; Edna Hardeman; Jürgen Götz
Journal:  Cell       Date:  2010-07-22       Impact factor: 41.582

4.  Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia.

Authors:  S Namura; K Iihara; S Takami; I Nagata; H Kikuchi; K Matsushita; M A Moskowitz; J V Bonventre; A Alessandrini
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-14       Impact factor: 11.205

5.  Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway.

Authors:  Aida Maddahi; Lars Edvinsson
Journal:  J Neuroinflammation       Date:  2010-02-26       Impact factor: 8.322

6.  Inhibition of MEK/ERK 1/2 pathway reduces pro-inflammatory cytokine interleukin-1 expression in focal cerebral ischemia.

Authors:  Zhi-Qiu Wang; Du-Chu Wu; Feng-Ping Huang; Guo-Yuan Yang
Journal:  Brain Res       Date:  2004-01-16       Impact factor: 3.252

7.  Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia.

Authors:  E S Connolly; C J Winfree; D M Stern; R A Solomon; D J Pinsky
Journal:  Neurosurgery       Date:  1996-03       Impact factor: 4.654

8.  Effects of extracellular signal-regulated kinase (ERK) on focal cerebral ischemia.

Authors:  Zhiqiu Wang; Xiancheng Chen; Liangfu Zhou; Duchu Wu; Xiaoming Che; Guoyuan Yang
Journal:  Chin Med J (Engl)       Date:  2003-10       Impact factor: 2.628

9.  Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.

Authors:  R P Simon; J H Swan; T Griffiths; B S Meldrum
Journal:  Science       Date:  1984-11-16       Impact factor: 47.728

10.  Enhanced expressions of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway.

Authors:  Aida Maddahi; Lars Edvinsson
Journal:  BMC Neurosci       Date:  2008-09-15       Impact factor: 3.288
View more
  13 in total

1.  Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke.

Authors:  David Yang-Wei Fann; Yun-An Lim; Yi-Lin Cheng; Ker-Zhing Lok; Prasad Chunduri; Sang-Ha Baik; Grant R Drummond; S Thameem Dheen; Christopher G Sobey; Dong-Gyu Jo; Christopher Li-Hsian Chen; Thiruma V Arumugam
Journal:  Mol Neurobiol       Date:  2017-01-14       Impact factor: 5.590

2.  Pathways Involved in Oxygen Glucose Deprivation Damage of Astrocytes.

Authors:  Shuyong Wei; Jie Tong; Qiang Xue; Yang Liu; Xiaoyu Xu
Journal:  J Mol Neurosci       Date:  2016-09-06       Impact factor: 3.444

Review 3.  The Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway as a Discovery Target in Stroke.

Authors:  Jing Sun; Guangxian Nan
Journal:  J Mol Neurosci       Date:  2016-02-03       Impact factor: 3.444

4.  GPR55 promotes migration and adhesion of colon cancer cells indicating a role in metastasis.

Authors:  J Kargl; L Andersen; C Hasenöhrl; D Feuersinger; A Stančić; A Fauland; C Magnes; A El-Heliebi; S Lax; S Uranitsch; J Haybaeck; A Heinemann; R Schicho
Journal:  Br J Pharmacol       Date:  2015-11-25       Impact factor: 8.739

5.  Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood-brain barrier damage, and inflammation.

Authors:  Jonas Leinweber; Daniella M Mizurini; Ivo M B Francischetti; Michael Fleischer; Dirk M Hermann; Christoph Kleinschnitz; Friederike Langhauser
Journal:  Brain Behav Immun       Date:  2021-01-02       Impact factor: 7.217

6.  Up-regulated microRNA-199b-3p represses the apoptosis of cerebral microvascular endothelial cells in ischemic stroke through down-regulation of MAPK/ERK/EGR1 axis.

Authors:  Ya-Xiong Yong; Hua Yang; Jia Lian; Xiao-Wei Xu; Ke Han; Ming-Yi Hu; Hua-Cheng Wang; Lie-Min Zhou
Journal:  Cell Cycle       Date:  2019-07-10       Impact factor: 5.173

7.  Dietary Sutherlandia and elderberry mitigate cerebral ischemia-induced neuronal damage and attenuate p47phox and phospho-ERK1/2 expression in microglial cells.

Authors:  Dennis Y Chuang; Jiankun Cui; Agnes Simonyi; Victoria A Engel; Shanyan Chen; Kevin L Fritsche; Andrew L Thomas; Wendy L Applequist; William R Folk; Dennis B Lubahn; Albert Y Sun; Grace Y Sun; Zezong Gu
Journal:  ASN Neuro       Date:  2014-10-16       Impact factor: 4.146

8.  2-Chloroethanol Induced Upregulation of Matrix Metalloproteinase-2 in Primary Cultured Rat Astrocytes Via MAPK Signal Pathways.

Authors:  Qi Sun; Yingjun Liao; Tong Wang; Hongge Tang; Gaoyang Wang; Fenghong Zhao; Yaping Jin
Journal:  Front Neurosci       Date:  2017-01-04       Impact factor: 4.677

Review 9.  Multi-Targeting Andrographolide, a Novel NF-κB Inhibitor, as a Potential Therapeutic Agent for Stroke.

Authors:  Chih-Hao Yang; Ting-Lin Yen; Chia-Yuan Hsu; Philip-Aloysius Thomas; Joen-Rong Sheu; Thanasekaran Jayakumar
Journal:  Int J Mol Sci       Date:  2017-07-27       Impact factor: 5.923

10.  Upregulation of Matrix Metalloproteinase-9 in Primary Cultured Rat Astrocytes Induced by 2-Chloroethanol Via MAPK Signal Pathways.

Authors:  Tong Wang; Yingjun Liao; Qi Sun; Hongge Tang; Gaoyang Wang; Fenghong Zhao; Yaping Jin
Journal:  Front Cell Neurosci       Date:  2017-07-19       Impact factor: 5.505
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.