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Literature DB >> 24336222

Establishment of methylation patterns in ES cells.

Ofra Sabag¹, Ayelet Zamir¹, Ilana Keshet¹, Merav Hecht², Guy Ludwig², Amalia Tabib², Joshua Moss², Howard Cedar².

Abstract

After erasure in the early animal embryo, a new bimodal DNA methylation pattern is regenerated at implantation. We have identified a demethylation pathway in mouse embryonic cells that uses hydroxymethylation (Tet1), deamination (Aid), glycosylation (Mbd4) and excision repair (Gadd45a) genes. Surprisingly, this demethylation system is not necessary for generating the overall bimodal methylation pattern but does appear to be involved in resetting methylation patterns during somatic-cell reprogramming.

Entities: Gene Species

Mesh：

Year: 2013 PMID： 24336222 DOI： 10.1038/nsmb.2734

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

30 in total

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2. DNA-binding factors shape the mouse methylome at distal regulatory regions.

Authors: Michael B Stadler; Rabih Murr; Lukas Burger; Robert Ivanek; Florian Lienert; Anne Schöler; Erik van Nimwegen; Christiane Wirbelauer; Edward J Oakeley; Dimos Gaidatzis; Vijay K Tiwari; Dirk Schübeler
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3. Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract.

Authors: Christel T Freberg; John Arne Dahl; Sanna Timoskainen; Philippe Collas
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4. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.

Authors: Kristine Williams; Jesper Christensen; Marianne Terndrup Pedersen; Jens V Johansen; Paul A C Cloos; Juri Rappsilber; Kristian Helin
Journal: Nature Date: 2011-04-13 Impact factor: 49.962

5. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.

Authors: Yu-Fei He; Bin-Zhong Li; Zheng Li; Peng Liu; Yang Wang; Qingyu Tang; Jianping Ding; Yingying Jia; Zhangcheng Chen; Lin Li; Yan Sun; Xiuxue Li; Qing Dai; Chun-Xiao Song; Kangling Zhang; Chuan He; Guo-Liang Xu
Journal: Science Date: 2011-08-04 Impact factor: 47.728

6. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines.

Authors: F Antequera; J Boyes; A Bird
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7. Evidence for an instructive mechanism of de novo methylation in cancer cells.

Authors: Ilana Keshet; Yeshayahu Schlesinger; Shlomit Farkash; Eyal Rand; Merav Hecht; Eran Segal; Eli Pikarski; Richard A Young; Alain Niveleau; Howard Cedar; Itamar Simon
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8. Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.

Authors: Victoria Valinluck; Lawrence C Sowers
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9. Sp1 elements protect a CpG island from de novo methylation.

Authors: M Brandeis; D Frank; I Keshet; Z Siegfried; M Mendelsohn; A Nemes; V Temper; A Razin; H Cedar
Journal: Nature Date: 1994-09-29 Impact factor: 49.962

10. Base excision DNA repair defect in Gadd45a-deficient cells.

Authors: H J Jung; E H Kim; J-Y Mun; S Park; M L Smith; S S Han; Y R Seo
Journal: Oncogene Date: 2007-06-18 Impact factor: 9.867

16 in total

1. Role of transcription complexes in the formation of the basal methylation pattern in early development.

Authors: Razi Greenfield; Amalia Tabib; Ilana Keshet; Joshua Moss; Ofra Sabag; Alon Goren; Howard Cedar
Journal: Proc Natl Acad Sci U S A Date: 2018-09-26 Impact factor: 11.205

Review 2. Defining, distinguishing and detecting the contribution of heterogeneous methylation to cancer heterogeneity.

Authors: Thomas R Pisanic; Pornpat Athamanolap; Tza-Huei Wang
Journal: Semin Cell Dev Biol Date: 2016-08-28 Impact factor: 7.727

Review 3. Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites.

Authors: Alfonso Bellacosa; Alexander C Drohat
Journal: DNA Repair (Amst) Date: 2015-05-01

Review 4. Role of Base Excision "Repair" Enzymes in Erasing Epigenetic Marks from DNA.

Authors: Alexander C Drohat; Christopher T Coey
Journal: Chem Rev Date: 2016-08-08 Impact factor: 60.622

5. Tracing dynamic changes of DNA methylation at single-cell resolution.

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6. Aberrant DNA methylation in ES cells.

Authors: Guy Ludwig; Deborah Nejman; Merav Hecht; Shari Orlanski; Monther Abu-Remaileh; Ofra Yanuka; Oded Sandler; Amichai Marx; Douglas Roberts; Nissim Benvenisty; Yehudit Bergman; Monica Mendelsohn; Howard Cedar
Journal: PLoS One Date: 2014-05-22 Impact factor: 3.240