| Literature DB >> 24336200 |
Liang Jiang1, Xue Liu1, Guosheng Xiong1, Huihui Liu1, Fulu Chen2, Lei Wang2, Xiangbing Meng2, Guifu Liu2, Hong Yu2, Yundong Yuan2, Wei Yi3, Lihua Zhao3, Honglei Ma3, Yuanzheng He4, Zhongshan Wu4, Karsten Melcher4, Qian Qian5, H Eric Xu6, Yonghong Wang2, Jiayang Li2.
Abstract
Strigolactones (SLs) are a group of newly identified plant hormones that control plant shoot branching. SL signalling requires the hormone-dependent interaction of DWARF 14 (D14), a probable candidate SL receptor, with DWARF 3 (D3), an F-box component of the Skp-Cullin-F-box (SCF) E3 ubiquitin ligase complex. Here we report the characterization of a dominant SL-insensitive rice (Oryza sativa) mutant dwarf 53 (d53) and the cloning of D53, which encodes a substrate of the SCF(D3) ubiquitination complex and functions as a repressor of SL signalling. Treatments with GR24, a synthetic SL analogue, cause D53 degradation via the proteasome in a manner that requires D14 and the SCF(D3) ubiquitin ligase, whereas the dominant form of D53 is resistant to SL-mediated degradation. Moreover, D53 can interact with transcriptional co-repressors known as TOPLESS-RELATED PROTEINS. Our results suggest a model of SL signalling that involves SL-dependent degradation of the D53 repressor mediated by the D14-D3 complex.Entities:
Mesh：
Substances：
Year: 2013 PMID： 24336200 PMCID： PMC5802366 DOI： 10.1038/nature12870
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962