Literature DB >> 24335895

Use of acellular dermal regeneration template combined with NPWT to treat complicated extremity wounds in children.

R L Hutchison1, J R Craw2.   

Abstract

OBJECTIVE: The treatment of open wounds with exposed bone, tendon, or nerve is a challenging reconstructive problem, especially in children. The purpose of this study is to evaluate the safety and effectiveness of using acellular dermal templates combined with negative pressure wound dressings in the treatment of complicated paediatric soft tissue extremity wounds.
METHOD: A retrospective review of eight patients treated with acellular dermal templates for closure of complicated extremity wounds was performed. After debridement, all patients were treated with a template and a negative pressure wound treatment (NPWT) system.
RESULTS: The average age was 8.8 years with 4 females and 4 males. Four wounds were at the foot/ankle, with tendon exposed in all 4, nerve in 2, and bone in 3. There were 3 lower leg wounds, all with exposed bone. One patient had arm/hand wounds with exposed tendon. The size of the wounds and dermal graft averaged 86cm² and 57cm². The average time to wound closure was 65 days. The majority of the treatment was received as an outpatient, including NPWT. For inpatient and outpatient care, the average number of sponge system changes was 2.6 compared to 4.6, and time between changes was 3.5 compared to 6.8 days. Each patient had only one procedure each for application of the dermal substitute and later one skin grafting procedure. Complications were minimal, and all patients healed their wounds without the need of flaps. One patient required wound revision.
CONCLUSION: Our study demonstrates that a dermal template combined with NPWT can safely and effectively be used to treat complicated wounds in children. Closure was obtained without flaps, the majority of the treatment time was spent in the outpatient setting, and the complication rate was low. DECLARATION OF INTEREST: There were no external sources of funding for this study. The authors have no conflicts of interest to declare.

Entities:  

Mesh:

Year:  2013        PMID: 24335895     DOI: 10.12968/jowc.2013.22.12.708

Source DB:  PubMed          Journal:  J Wound Care        ISSN: 0969-0700            Impact factor:   2.072


  5 in total

1.  Combination therapy of oxidised regenerated cellulose/collagen/silver dressings with negative pressure wound therapy for coverage of exposed critical structures in complex lower-extremity wounds.

Authors:  Mei Ling Loh; Benjamin K L Goh; Yuan Kong; George Varughese; Jia Lin Ng; Zhiwen J Lo; Chong Han Pek
Journal:  Int Wound J       Date:  2020-05-24       Impact factor: 3.315

2.  Flap decisions and options in soft tissue coverage of the lower limb.

Authors:  Daniel J Jordan; Marco Malahias; Sandip Hindocha; Ali Juma
Journal:  Open Orthop J       Date:  2014-10-31

3.  Combination of negative pressure wound therapy (NPWT) and integra dermal regeneration template (IDRT) in the lower extremity wound; Our experience with 4 cases.

Authors:  Attia Attia; Tarek Elmenoufy; Tarek Atta; Ahmed Harfoush; Sayed Tarek
Journal:  JPRAS Open       Date:  2020-04-08

Review 4.  Clinical applications of acellular dermal matrices: A review.

Authors:  Kyla Petrie; Cameron T Cox; Benjamin C Becker; Brendan J MacKay
Journal:  Scars Burn Heal       Date:  2022-01-19

5.  Reconstruction of full thickness wounds using glyaderm in a single-staged procedure.

Authors:  Melissa de Henau; Anne Sophie Kruit; Dietmar J O Ulrich
Journal:  Cell Tissue Bank       Date:  2021-02-23       Impact factor: 1.522

  5 in total

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