BACKGROUND: The number of endothelial progenitor cells (EPCs) descends when atherosclerosis developed. The objective was to compare the number of CD34(+)CD133(+) cells with the severity of atherosclerosis assessed by Syntax score. METHODS: The study included 80 patients with stable angina undergoing coronary angiography. Patients were classified into single-vessel group, multiple-vessel group and normal group according to angiography. The percentage of CD34(+)CD133(+) cells in the mononuclear cells isolated from peripheral blood of different groups by flow cytometric analysis was compared. The quantity of CD34(+)CD133(+) EPCs was log transformed to improve normality (lgEPC). Syntax score was used in this study to assess the extent of coronary artery disease. RESULTS: The level of lgEPC was lower in the single-vessel group than that in the normal group (-3.42 ± 0.44 versus -3.17 ± 0.39, P < 0.05), and the level of lgEPC was lower in the multiple-vessel group than that in the single vessel group (-3.63 ± 0.31 versus -3.42 ± 0.44, P < 0.05). An inverse correlation between lgEPC and Syntax score analyzed by linear regression. CONCLUSIONS: EPC level probably serves as a predictor of the development and severity of atherosclerosis on a cellular level. EPC, a relatively more important risk factor, perhaps protects against coronary artery disease.
BACKGROUND: The number of endothelial progenitor cells (EPCs) descends when atherosclerosis developed. The objective was to compare the number of CD34(+)CD133(+) cells with the severity of atherosclerosis assessed by Syntax score. METHODS: The study included 80 patients with stable angina undergoing coronary angiography. Patients were classified into single-vessel group, multiple-vessel group and normal group according to angiography. The percentage of CD34(+)CD133(+) cells in the mononuclear cells isolated from peripheral blood of different groups by flow cytometric analysis was compared. The quantity of CD34(+)CD133(+) EPCs was log transformed to improve normality (lgEPC). Syntax score was used in this study to assess the extent of coronary artery disease. RESULTS: The level of lgEPC was lower in the single-vessel group than that in the normal group (-3.42 ± 0.44 versus -3.17 ± 0.39, P < 0.05), and the level of lgEPC was lower in the multiple-vessel group than that in the single vessel group (-3.63 ± 0.31 versus -3.42 ± 0.44, P < 0.05). An inverse correlation between lgEPC and Syntax score analyzed by linear regression. CONCLUSIONS: EPC level probably serves as a predictor of the development and severity of atherosclerosis on a cellular level. EPC, a relatively more important risk factor, perhaps protects against coronary artery disease.
Authors: Trevor Simard; Richard G Jung; Pouya Motazedian; Pietro Di Santo; F Daniel Ramirez; Juan J Russo; Alisha Labinaz; Altayyeb Yousef; Brijesh Anantharam; Ali Pourdjabbar; Benjamin Hibbert Journal: Stem Cells Int Date: 2017-01-23 Impact factor: 5.443
Authors: Sylvia Otto; Kristina Nitsche; Christian Jung; Aleh Kryvanos; Andrey Zhylka; Kerstin Heitkamp; Juan-Luis Gutiérrez-Chico; Björn Goebel; P Christian Schulze; Hans R Figulla; Tudor C Poerner Journal: BMC Cardiovasc Disord Date: 2017-04-26 Impact factor: 2.298
Authors: José C Jaime-Pérez; César D Villarreal-Villarreal; Eduardo Vázquez-Garza; Nereida Méndez-Ramírez; Rosario Salazar-Riojas; David Gómez-Almaguer Journal: Data Brief Date: 2016-03-31