Literature DB >> 24335294

Hantavirus Gn and Gc glycoproteins self-assemble into virus-like particles.

Rodrigo Acuña1, Nicolás Cifuentes-Muñoz, Chantal L Márquez, Manuela Bulling, Jonas Klingström, Roberta Mancini, Pierre-Yves Lozach, Nicole D Tischler.   

Abstract

How hantaviruses assemble and exit infected cells remains largely unknown. Here, we show that the expression of Andes (ANDV) and Puumala (PUUV) hantavirus Gn and Gc envelope glycoproteins lead to their self-assembly into virus-like particles (VLPs) which were released to cell supernatants. The viral nucleoprotein was not required for particle formation. Further, a Gc endodomain deletion mutant did not abrogate VLP formation. The VLPs were pleomorphic, exposed protrusions and reacted with patient sera.

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Year:  2013        PMID： 24335294      PMCID： PMC3911568          DOI： 10.1128/JVI.03118-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  38 in total

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4.  Ultrastructural characteristics of Sin Nombre virus, causative agent of hantavirus pulmonary syndrome.

Authors:  C S Goldsmith; L H Elliott; C J Peters; S R Zaki
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574

5.  Generation and analysis of infectious virus-like particles of uukuniemi virus (bunyaviridae): a useful system for studying bunyaviral packaging and budding.

Authors:  Anna K Overby; Vsevolod Popov; Etienne P A Neve; Ralf F Pettersson
Journal:  J Virol       Date:  2006-08-23       Impact factor: 5.103

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Authors:  C Schmaljohn; B Hjelle
Journal:  Emerg Infect Dis       Date:  1997 Apr-Jun       Impact factor: 6.883

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8.  Andes virus antigens are shed in urine of patients with acute hantavirus cardiopulmonary syndrome.

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Journal:  J Virol       Date:  2009-03-11       Impact factor: 5.103

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Journal:  J Virol       Date:  2007-07-03       Impact factor: 5.103

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  15 in total

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Journal:  Nature       Date:  2018-11-21       Impact factor: 49.962

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Review 3.  Hantavirus Gn and Gc envelope glycoproteins: key structural units for virus cell entry and virus assembly.

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Journal:  Viruses       Date:  2014-04-21       Impact factor: 5.048

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5.  Crystal Structure of Glycoprotein C from a Hantavirus in the Post-fusion Conformation.

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Journal:  PLoS Pathog       Date:  2016-10-26       Impact factor: 6.823

6.  Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc.

Authors:  Pablo Guardado-Calvo; Eduardo A Bignon; Eva Stettner; Scott Allen Jeffers; Jimena Pérez-Vargas; Gerard Pehau-Arnaudet; M Alejandra Tortorici; Jean-Luc Jestin; Patrick England; Nicole D Tischler; Félix A Rey
Journal:  PLoS Pathog       Date:  2016-10-26       Impact factor: 6.823

7.  Self-association and subcellular localization of Puumala hantavirus envelope proteins.

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8.  Two Point Mutations in Old World Hantavirus Glycoproteins Afford the Generation of Highly Infectious Recombinant Vesicular Stomatitis Virus Vectors.

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9.  Molecular organization and dynamics of the fusion protein Gc at the hantavirus surface.

Authors:  Eduardo A Bignon; Amelina Albornoz; Pablo Guardado-Calvo; Félix A Rey; Nicole D Tischler
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10.  Construction and immunological characterization of CD40L or GM-CSF incorporated Hantaan virus like particle.

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