Anthony V Perruccio1, Nizar N Mahomed, Vinod Chandran, Rajiv Gandhi. 1. From the Arthritis Program, Toronto Western Hospital, University Health Network; Institute of Health Policy, Management and Evaluation; Toronto Musculoskeletal Centre, University of Toronto; Division of Orthopedic Surgery, Department of Surgery, and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Abstract
OBJECTIVE: To investigate the association between plasma adipokine levels and the burden of painful joints among individuals with hip and knee osteoarthritis (OA). METHODS: Adipokines (leptin, adiponectin, adipsin, resistin) were determined by ELISA (n = 78). Individuals reported painful joints on a homunculus. Associations were examined by sex-stratified Poisson analyses. RESULTS: Adjusted for age, body mass index, and hip/knee OA, higher leptin and adiponectin and lower adipsin levels were associated with greater painful joint burden (i.e., counts) among women (p < 0.01). Among men, higher resistin levels were associated with lower counts (p = 0.03). CONCLUSION: Findings support the likelihood of a systemic-dependent sex-specific pain burden among individuals with OA.
OBJECTIVE: To investigate the association between plasma adipokine levels and the burden of painful joints among individuals with hip and knee osteoarthritis (OA). METHODS: Adipokines (leptin, adiponectin, adipsin, resistin) were determined by ELISA (n = 78). Individuals reported painful joints on a homunculus. Associations were examined by sex-stratified Poisson analyses. RESULTS: Adjusted for age, body mass index, and hip/knee OA, higher leptin and adiponectin and lower adipsin levels were associated with greater painful joint burden (i.e., counts) among women (p < 0.01). Among men, higher resistin levels were associated with lower counts (p = 0.03). CONCLUSION: Findings support the likelihood of a systemic-dependent sex-specific pain burden among individuals with OA.
Authors: Nurten Seringec Akkececi; Gozen Oksuz; Aykut Urfalioğlu; Ramazan Gunesacar; Murat Bakacak; Mahmut Arslan; Bekir Mehmet Kelleci Journal: Med Princ Pract Date: 2019-04-26 Impact factor: 1.927
Authors: Marthe Gløersen; Pernille Steen Pettersen; Tuhina Neogi; S Reza Jafarzadeh; Maria Vistnes; Christian S Thudium; Anne-Christine Bay-Jensen; Joe Sexton; Tore K Kvien; Hilde B Hammer; Ida K Haugen Journal: Arthritis Rheumatol Date: 2022-03-23 Impact factor: 15.483
Authors: Cristóbal Orellana; Joan Calvet; Antoni Berenguer-Llergo; Néstor Albiñana; María García Manrique; Carlos Galisteo Lencastre; Marta Arévalo; María Llop; Assumpta Caixàs; Jordi Gratacós Journal: Cartilage Date: 2020-02-20 Impact factor: 3.117