Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Abnormal kalirin signaling in neuropsychiatric disorders.

Literature DB >> 24334022

Abnormal kalirin signaling in neuropsychiatric disorders.

Christine Remmers¹, Robert A Sweet², Peter Penzes³.

Abstract

Changes in dendritic spines structure and function play a critical role in a number of physiological processes, including synaptic transmission and plasticity, and are intimately linked to cognitive function. Alterations in dendritic spine morphogenesis occur in a number of neuropsychiatric disorders and likely underlie the cognitive and behavioral changes associated with these disorders. The neuronal guanine nucleotide exchange factor (GEF) kalirin is emerging as a key regulator of structural and functional plasticity at dendritic spines. Moreover, a series of recent studies have genetically and functionally linked kalirin signaling to several disorders, including schizophrenia and Alzheimer's disease. Kalirin signaling may thus represent a disease mechanism and provide a novel therapeutic target.

Entities: Chemical

Keywords: Alzheimer's disease; Genetic; Glutamatergic; Mental disorder; Postmortem; Schizophrenia

Mesh：

Substances：

Year: 2013 PMID： 24334022 PMCID： PMC3989394 DOI： 10.1016/j.brainresbull.2013.12.006

Source DB: PubMed Journal: Brain Res Bull ISSN： 0361-9230 Impact factor: 4.077

108 in total

Review 1. Alzheimer's disease is a synaptic failure.

Authors: Dennis J Selkoe
Journal: Science Date: 2002-10-25 Impact factor: 47.728

2. Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling.

Authors: Kelly A Jones; Deepak P Srivastava; John A Allen; Ryan T Strachan; Bryan L Roth; Peter Penzes
Journal: Proc Natl Acad Sci U S A Date: 2009-11-04 Impact factor: 11.205

3. Abnormalities of the Duo/Ras-related C3 botulinum toxin substrate 1/p21-activated kinase 1 pathway drive myosin light chain phosphorylation in frontal cortex in schizophrenia.

Authors: María D Rubio; Vahram Haroutunian; James H Meador-Woodruff
Journal: Biol Psychiatry Date: 2012-03-27 Impact factor: 13.382

Review 4. Control of synapse development and plasticity by Rho GTPase regulatory proteins.

Authors: Kimberley F Tolias; Joseph G Duman; Kyongmi Um
Journal: Prog Neurobiol Date: 2011-04-22 Impact factor: 11.685

5. Microdeletions of 3q29 confer high risk for schizophrenia.

Authors: Jennifer Gladys Mulle; Anne F Dodd; John A McGrath; Paula S Wolyniec; Adele A Mitchell; Amol C Shetty; Nara L Sobreira; David Valle; M Katharine Rudd; Glen Satten; David J Cutler; Ann E Pulver; Stephen T Warren
Journal: Am J Hum Genet Date: 2010-08-13 Impact factor: 11.025

6. Kalirin inhibition of inducible nitric-oxide synthase.

Authors: E A Ratovitski; M R Alam; R A Quick; A McMillan; C Bao; C Kozlovsky; T A Hand; R C Johnson; R E Mains; B A Eipper; C J Lowenstein
Journal: J Biol Chem Date: 1999-01-08 Impact factor: 5.157

7. Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines.

Authors: Zhong Xie; Deepak P Srivastava; Huzefa Photowala; Li Kai; Michael E Cahill; Kevin M Woolfrey; Cassandra Y Shum; D James Surmeier; Peter Penzes
Journal: Neuron Date: 2007-11-21 Impact factor: 17.173

Review 8. Neuregulin 1 in neural development, synaptic plasticity and schizophrenia.

Authors: Lin Mei; Wen-Cheng Xiong
Journal: Nat Rev Neurosci Date: 2008-05-14 Impact factor: 34.870

9. Genomewide association studies of stroke.

Authors: M Arfan Ikram; Sudha Seshadri; Joshua C Bis; Myriam Fornage; Anita L DeStefano; Yurii S Aulchenko; Stephanie Debette; Thomas Lumley; Aaron R Folsom; Evita G van den Herik; Michiel J Bos; Alexa Beiser; Mary Cushman; Lenore J Launer; Eyal Shahar; Maksim Struchalin; Yangchun Du; Nicole L Glazer; Wayne D Rosamond; Fernando Rivadeneira; Margaret Kelly-Hayes; Oscar L Lopez; Josef Coresh; Albert Hofman; Charles DeCarli; Susan R Heckbert; Peter J Koudstaal; Qiong Yang; Nicholas L Smith; Carlos S Kase; Kenneth Rice; Talin Haritunians; Gerwin Roks; Paul L M de Kort; Kent D Taylor; Lonneke M de Lau; Ben A Oostra; Andre G Uitterlinden; Jerome I Rotter; Eric Boerwinkle; Bruce M Psaty; Thomas H Mosley; Cornelia M van Duijn; Monique M B Breteler; W T Longstreth; Philip A Wolf
Journal: N Engl J Med Date: 2009-04-15 Impact factor: 91.245

10. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system.

Authors: Claudia S Barros; Barbara Calabrese; Pablo Chamero; Amanda J Roberts; Ed Korzus; Kent Lloyd; Lisa Stowers; Mark Mayford; Shelley Halpain; Ulrich Müller
Journal: Proc Natl Acad Sci U S A Date: 2009-02-24 Impact factor: 11.205

19 in total

1. Scaffold protein X11α interacts with kalirin-7 in dendrites and recruits it to Golgi outposts.

Authors: Kelly A Jones; Andrew G Eng; Pooja Raval; Deepak P Srivastava; Peter Penzes
Journal: J Biol Chem Date: 2014-11-05 Impact factor: 5.157

2. Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers.

Authors: Zhong Xie; Lauren P Shapiro; Michael E Cahill; Theron A Russell; Pascale N Lacor; William L Klein; Peter Penzes
Journal: Eur J Neurosci Date: 2019-01-20 Impact factor: 3.386

Review 3. Reversing synapse loss in Alzheimer's disease: Rho-guanosine triphosphatases and insights from other brain disorders.

Authors: Roger Lefort
Journal: Neurotherapeutics Date: 2015-01 Impact factor: 7.620

Review 4. Altering the course of schizophrenia: progress and perspectives.

Authors: Mark J Millan; Annie Andrieux; George Bartzokis; Kristin Cadenhead; Paola Dazzan; Paolo Fusar-Poli; Jürgen Gallinat; Jay Giedd; Dennis R Grayson; Markus Heinrichs; René Kahn; Marie-Odile Krebs; Marion Leboyer; David Lewis; Oscar Marin; Philippe Marin; Andreas Meyer-Lindenberg; Patrick McGorry; Philip McGuire; Michael J Owen; Paul Patterson; Akira Sawa; Michael Spedding; Peter Uhlhaas; Flora Vaccarino; Claes Wahlestedt; Daniel Weinberger
Journal: Nat Rev Drug Discov Date: 2016-03-04 Impact factor: 84.694