Danielle Mendes da Camara1, Marcela Lumi Miyasaki1, Marcelle Danelon1, Kikue Takebayashi Sassaki2, Alberto Carlos Botazzo Delbem3. 1. Department of Pediatric Dentistry and Public Health, Araçatuba Dental School, UNESP - Univ Estadual Paulista, Araçatuba, São Paulo, Brazil. 2. Department of Basic Sciences, Araçatuba Dental School, UNESP - Univ Estadual Paulista, Araçatuba, São Paulo, Brazil. 3. Department of Pediatric Dentistry and Public Health, Araçatuba Dental School, UNESP - Univ Estadual Paulista, Araçatuba, São Paulo, Brazil. Electronic address: adelbem@foa.unesp.br.
Abstract
OBJECTIVES: The aim of this study was to evaluate the anticaries effect of low-fluoride toothpastes combined with hexametaphosphate (HMP) on enamel demineralization. METHODS: Bovine enamel blocks were subjected to pH cycling and treatment with toothpaste's slurries (15 groups; 2×/day). Toothpaste mixtures contained the following: no fluoride (F) plus HMP (from 0 to 3.0%); 250ppm F plus HMP (from 0 to 3.0%); 500ppm F; 1100ppm F; and a commercial toothpaste (1100ppm F). After pH cycling, surface and cross-sectional hardness, as well as F present in the enamel were determined. The demineralization depth was analyzed using polarized light microscopy. The variables were subjected to 1-way ANOVA, followed by Student-Newman-Keuls' test (p<0.05). RESULTS: In the absence of fluoride, 0.5% HMP promoted the lowest mineral loss and its effect was similar to that of a 250ppm F toothpaste (p>0.05). The combination of 0.5% HMP and 250ppm F resulted in lower mineral loss (p<0.05) and similar lesion depth when compared to the 1100ppm F toothpaste (p>0.05). CONCLUSION: To conclude, the combination of 0.5% HMP and 250ppm fluoride in a toothpaste has a similar inhibitory effect on enamel demineralization in vitro when compared to a toothpaste containing 1100ppm F. CLINICAL SIGNIFICANCE: The anticaries effect of toothpaste containing 250ppm F combined with 0.5% HMP was similar to that of a 1100ppm F toothpaste, despite the 4-fold difference in F concentration. Although such effects still need to be demonstrated in clinical studies, it may be a viable alternative for preschool children.
OBJECTIVES: The aim of this study was to evaluate the anticaries effect of low-fluoride toothpastes combined with hexametaphosphate (HMP) on enamel demineralization. METHODS:Bovine enamel blocks were subjected to pH cycling and treatment with toothpaste's slurries (15 groups; 2×/day). Toothpaste mixtures contained the following: no fluoride (F) plus HMP (from 0 to 3.0%); 250ppm F plus HMP (from 0 to 3.0%); 500ppm F; 1100ppm F; and a commercial toothpaste (1100ppm F). After pH cycling, surface and cross-sectional hardness, as well as F present in the enamel were determined. The demineralization depth was analyzed using polarized light microscopy. The variables were subjected to 1-way ANOVA, followed by Student-Newman-Keuls' test (p<0.05). RESULTS: In the absence of fluoride, 0.5% HMP promoted the lowest mineral loss and its effect was similar to that of a 250ppm F toothpaste (p>0.05). The combination of 0.5% HMP and 250ppm F resulted in lower mineral loss (p<0.05) and similar lesion depth when compared to the 1100ppm F toothpaste (p>0.05). CONCLUSION: To conclude, the combination of 0.5% HMP and 250ppm fluoride in a toothpaste has a similar inhibitory effect on enamel demineralization in vitro when compared to a toothpaste containing 1100ppm F. CLINICAL SIGNIFICANCE: The anticaries effect of toothpaste containing 250ppm F combined with 0.5% HMP was similar to that of a 1100ppm F toothpaste, despite the 4-fold difference in F concentration. Although such effects still need to be demonstrated in clinical studies, it may be a viable alternative for preschool children.
Authors: T E Robinson; N M Eisenstein; S C Cox; R J A Moakes; A M Thompson; Z Ahmed; E A B Hughes; L J Hill; S A Stapley; L M Grover Journal: Mater Today Bio Date: 2020-06-02