| Literature DB >> 24333726 |
Michael L O'Connor1, Dongxi Xiang1, Sarah Shigdar1, Joanna Macdonald1, Yong Li2, Tao Wang1, Chunwen Pu3, Zhidong Wang3, Liang Qiao4, Wei Duan5.
Abstract
Cancer stem cells are a progressive concept to account for the cell biological nature of cancer. Despite the controversies regarding the cancer stem cell model, it has the potential to provide a foundation for new innovative treatment targeting the roots of cancer. The last two years have witnessed exceptional progress in cancer stem cell research, in particular on solid tumours, which holds promise for improved treatment outcomes. Here, we review recent advances in cancer stem cell research, discuss challenges in the field and explore future strategies and opportunities in cancer stem cell studies to overcome resistance to chemotherapy.Entities:
Keywords: Aptamers; Cancer stem cells; Chemoresistance; Clonal evolution; Stemness
Mesh:
Year: 2013 PMID: 24333726 DOI: 10.1016/j.canlet.2013.11.012
Source DB: PubMed Journal: Cancer Lett ISSN: 0304-3835 Impact factor: 8.679