| Literature DB >> 24333398 |
Jing Lu1, Guoren Huang1, Sizhuo Hu1, Zhenning Wang1, Shuang Guan2.
Abstract
1,3-Dichloro-2-propanol (1,3-DCP) is a well-known contaminant that has been detected in a wide range of foods. Dietary intake represents the greatest source of exposure to 1,3-DCP. In the study, we first found 1,3-DCP could induce hyperlipidemia in C57BL/6J mice below 1 mg/kg/day. We investigated serum lipid profile, liver total cholesterol (TC) and triglyceride (TG), histopathology of Liver and adipose tissue. The results showed 1,3-DCP dose dependently increased serum TG, TC and low-density lipoprotein cholesterol (LDL-C), decreased serum high-density lipoprotein cholesterol (HDL-C), increased relative liver weight, liver TG and TC, relative adipose tissue weight and enlarged the size of adipose cells. Because AMPK signal pathway is important in the process of lipid metabolism, we further investigated the effects of 1,3-DCP on AMPK signaling pathway in murine models. The results showed that 1,3-DCP (0.1-1 mg/kg/day) decreased p-AMPK/tAMPK ratio, p-ACC/tACC ratio, PPARα expression, but increased FAT, SREBP1, HMGCR and FAS expression. These observations indicated that 1,3-DCP induced hyperlipidemia in C57BL/6J mice at least partially through regulating AMPK signaling pathway.Entities:
Keywords: 1,3-DCP; 1,3-dichloro-2-propanol; 3-hydroxy-3-methylglutaryl CoA reductase; ACC; AMPK; AMPK signaling pathway; FAS; FAT; FBS; HMGCR; Hyperlipidemia; In vivo; PPAR; SREBP; Sterol regulatory element-binding protein; acetyl-CoA carboxylase; adenosine 5′-monophosphate-activated protein kinase; fatty acid synthase; fatty acid translocase; fetal bovine serum; p-ACC; p-AMPK; peroxisome proliferator activated receptor; phosphorylated AMP-activated protein kinase; phosphorylated acetyl CoA carboxylase
Mesh：
Substances：
Year: 2013 PMID： 24333398 DOI： 10.1016/j.fct.2013.11.049
Source DB: PubMed Journal: Food Chem Toxicol ISSN： 0278-6915 Impact factor: 6.023