Janet E Bray1, Stephen Bernard2, Kate Cantwell3, Michael Stephenson4, Karen Smith5. 1. Department of Epidemiology and Preventive Medicine, Monash University, Level 5, The Alfred Centre, 99 Commercial Road, Melbourne, Victoria 3004, Australia. Electronic address: janet.bray@monash.edu. 2. Department of Epidemiology and Preventive Medicine, Monash University, Level 5, The Alfred Centre, 99 Commercial Road, Melbourne, Victoria 3004, Australia; Ambulance Victoria, 375 Manningham Road, Doncaster, Victoria 3108, Australia; Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia. 3. Department of Epidemiology and Preventive Medicine, Monash University, Level 5, The Alfred Centre, 99 Commercial Road, Melbourne, Victoria 3004, Australia; Ambulance Victoria, 375 Manningham Road, Doncaster, Victoria 3108, Australia; Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia. 4. Department of Epidemiology and Preventive Medicine, Monash University, Level 5, The Alfred Centre, 99 Commercial Road, Melbourne, Victoria 3004, Australia; Ambulance Victoria, 375 Manningham Road, Doncaster, Victoria 3108, Australia. 5. Department of Epidemiology and Preventive Medicine, Monash University, Level 5, The Alfred Centre, 99 Commercial Road, Melbourne, Victoria 3004, Australia; Ambulance Victoria, 375 Manningham Road, Doncaster, Victoria 3108, Australia; Department of Emergency Medicine, University of Western Australia, Perth, Western Australia, Australia.
Abstract
BACKGROUND: The optimal blood pressure target following successful resuscitation from out-of-hospital cardiac arrest (OHCA) is uncertain. This study aimed to explore the association between level of systolic blood pressure (SBP) on arrival at hospital and survival to hospital discharge. METHODS: We analysed eligible OHCAs occurring between January 2003 and December 2011 from the Victorian Ambulance Cardiac Arrest Register (VACAR). Inclusion criteria were: adults (≥18 years), presumed cardiac aetiology, not paramedic witnessed, and ROSC at hospital arrival. Multivariate logistic regression models were performed by initial rhythm (shockable/non-shockable) to examine the relationship between SBP at hospital arrival in 10 mmHg increments and survival to hospital discharge. Models were adjusted for known predictors of survival, including duration of arrest. RESULTS: Of 3620 eligible cases, 14% were hypotensive (SBP<90 mmHg) on hospital arrival (10% shockable and 19% non-shockable). For patients in shockable rhythms, discharge survival was maximal at 120-129 mmHg (54%), and in the adjusted model (≥120 mmHg as reference) SBP decrements below 90 mmHg were associated with lower survival: 80-89 mmHg AOR=0.49 (95% CI: 0.24-0.95); <80 mmHg AOR=0.24 (95% CI: 0.10-0.61); unrecordable AOR=0.10 (95% CI: 0.04-0.30). In patients found in non-shockable rhythms, SBP was not significant associated with discharge survival (AOR=1.01, 95% CI: 0.89-1.15). CONCLUSIONS: In an EMS system using intravenous adrenaline and fluids to maintain post-resuscitation SBP at 120 mmHg, hypotension on hospital arrival was relatively uncommon. However, in presumed cardiac OHCA patients with an initial shockable rhythm, SBPs below 90 mmHg was associated with significant lower odds of survival to hospital discharge. This level of hypotension may indicate patients who require more aggressive post-resuscitation blood pressure management.
BACKGROUND: The optimal blood pressure target following successful resuscitation from out-of-hospital cardiac arrest (OHCA) is uncertain. This study aimed to explore the association between level of systolic blood pressure (SBP) on arrival at hospital and survival to hospital discharge. METHODS: We analysed eligible OHCAs occurring between January 2003 and December 2011 from the Victorian Ambulance Cardiac Arrest Register (VACAR). Inclusion criteria were: adults (≥18 years), presumed cardiac aetiology, not paramedic witnessed, and ROSC at hospital arrival. Multivariate logistic regression models were performed by initial rhythm (shockable/non-shockable) to examine the relationship between SBP at hospital arrival in 10 mmHg increments and survival to hospital discharge. Models were adjusted for known predictors of survival, including duration of arrest. RESULTS: Of 3620 eligible cases, 14% were hypotensive (SBP<90 mmHg) on hospital arrival (10% shockable and 19% non-shockable). For patients in shockable rhythms, discharge survival was maximal at 120-129 mmHg (54%), and in the adjusted model (≥120 mmHg as reference) SBP decrements below 90 mmHg were associated with lower survival: 80-89 mmHg AOR=0.49 (95% CI: 0.24-0.95); <80 mmHg AOR=0.24 (95% CI: 0.10-0.61); unrecordable AOR=0.10 (95% CI: 0.04-0.30). In patients found in non-shockable rhythms, SBP was not significant associated with discharge survival (AOR=1.01, 95% CI: 0.89-1.15). CONCLUSIONS: In an EMS system using intravenous adrenaline and fluids to maintain post-resuscitation SBP at 120 mmHg, hypotension on hospital arrival was relatively uncommon. However, in presumed cardiac OHCApatients with an initial shockable rhythm, SBPs below 90 mmHg was associated with significant lower odds of survival to hospital discharge. This level of hypotension may indicate patients who require more aggressive post-resuscitation blood pressure management.
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