Houda Fagouri1, Driss Rahali Moussaoui2, Jaoud Kouach2, Abdelah Babahabib2, Mohamed Oukabli3, Ahmed Ameur4, Abderrahmane Albouzidi3, Mohamed Dehayni2. 1. Department of Obstetrics and Gynaecology, Military Hospital Mohamed V, CHU Ibn Sina, Rabat, Morocco. Electronic address: houdhoudf14@gmail.com. 2. Department of Obstetrics and Gynaecology, Military Hospital Mohamed V, CHU Ibn Sina, Rabat, Morocco. 3. Department of Histopathology, Military Hospital Mohamed V, CHU Ibn Sina, Rabat, Morocco. 4. Department of Urology, Military Hospital Mohamed V, CHU Ibn Sina, Rabat, Morocco.
Abstract
BACKGROUND: The complete androgen insensitivity (testicular feminization) syndrome was described in phenotypic females with 46XY karyotype, presenting with primary amenorrhea, adequate breast development, and absent or sparse pubic or axillary hair. Gonads consist usually of seminiferous tubules without spermatogenesis. CASE: We report the case of a 15-year-old girl with testicular feminization since age 4. She was admitted to surgically remove the testes from the inguinal canal. Microscopic examination of the left testis revealed a Sertoli-Leydig cell tumor and the draft of fallopian tube with adjacent seminiferous tubules. SUMMARY AND CONCLUSION: These patients have a 5%-10% risk of developing germ cell tumors. Sertoli-Leydig cell tumors are uncommon neoplasms, usually benign in testicular feminization syndrome.
BACKGROUND: The complete androgen insensitivity (testicular feminization) syndrome was described in phenotypic females with 46XY karyotype, presenting with primary amenorrhea, adequate breast development, and absent or sparse pubic or axillary hair. Gonads consist usually of seminiferous tubules without spermatogenesis. CASE: We report the case of a 15-year-old girl with testicular feminization since age 4. She was admitted to surgically remove the testes from the inguinal canal. Microscopic examination of the left testis revealed a Sertoli-Leydig cell tumor and the draft of fallopian tube with adjacent seminiferous tubules. SUMMARY AND CONCLUSION: These patients have a 5%-10% risk of developing germ cell tumors. Sertoli-Leydig cell tumors are uncommon neoplasms, usually benign in testicular feminization syndrome.