Leonard Kounegnigan Rerambiah1, Laurence Essola Rerambiah2, Calixte Bengone1, Joel F Djoba Siawaya3. 1. National Blood Transfusion Centre (CNTS), Libreville, Gabonese Republic. 2. University Hospital Centre of Libreville (CHUL), Libreville, Gabonese Republic. 3. National Blood Transfusion Centre (CNTS), Libreville, Gabonese Republic Specialised Diagnostics and Research Unit, National Public Health Laboratory (URDS/LNSP), Libreville, Gabonese Republic.
Abstract
BACKGROUND: Blood transfusions carry the risk of transmitting blood-borne infections. In contrast to the situation in the developed world, there is a limited number of studies examining this problem in sub-Saharan Africa. In this study we aimed to calculate the risks of acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection from units of blood issued by the Gabonese Blood Transfusion Centre between 2009 and 2011. MATERIALS AND METHODS: All the donations were tested for infectious diseases and the seroconversion incidence rates of HIV, HBV and HCV were calculated. The residual risk of transfusion-associated transmission for each virus was calculated by multiplying the seroconversion rates by the window period expressed in fractions of a year. RESULTS: The risks of becoming infected with HIV, HCV, and HBV in subjects receiving units of blood from the Gabonese Blood Transfusion Centre were 64.7, 207.94 and 534.53 per million donations, respectively. CONCLUSIONS: This study, which is the first to quantify the true risks of transfusion-transmitted infections in Gabon, reveals and confirms the need to reinforce preventative and screening strategies to improve transfusion safety in sub-Saharan Africa.
BACKGROUND: Blood transfusions carry the risk of transmitting blood-borne infections. In contrast to the situation in the developed world, there is a limited number of studies examining this problem in sub-Saharan Africa. In this study we aimed to calculate the risks of acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection from units of blood issued by the Gabonese Blood Transfusion Centre between 2009 and 2011. MATERIALS AND METHODS: All the donations were tested for infectious diseases and the seroconversion incidence rates of HIV, HBV and HCV were calculated. The residual risk of transfusion-associated transmission for each virus was calculated by multiplying the seroconversion rates by the window period expressed in fractions of a year. RESULTS: The risks of becoming infected with HIV, HCV, and HBV in subjects receiving units of blood from the Gabonese Blood Transfusion Centre were 64.7, 207.94 and 534.53 per million donations, respectively. CONCLUSIONS: This study, which is the first to quantify the true risks of transfusion-transmitted infections in Gabon, reveals and confirms the need to reinforce preventative and screening strategies to improve transfusion safety in sub-Saharan Africa.
Authors: Kuan A Traoré; Jean Bienvenue Ouoba; Hortense Rouamba; Yacouba K Nébié; Honorine Dahourou; Frédéric Rossetto; Alfred S Traoré; Nicolas Barro; Pierre Roques Journal: Emerg Infect Dis Date: 2016-04 Impact factor: 6.883
Authors: Jean Marie Eko Mba; Cyrille Bisseye; Jophrette Mireille Ntsame Ndong; Landry Erik Mombo; Calixte Bengone; Guy Mouelet Migolet; Bertrand M'batchi; Heidi E Kosiorek; Richard J Butterfield; Lewis R Roberts; Mitesh J Borad; Bolni Marius Nagalo Journal: PLoS One Date: 2018-04-13 Impact factor: 3.240