| Literature DB >> 24332927 |
Paolo Biancheri1, Paolo Giuffrida2, Guillermo H Docena3, Thomas T MacDonald4, Gino Roberto Corazza2, Antonio Di Sabatino5.
Abstract
Transforming growth factor (TGF)-β, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-β also enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-β signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-β signaling in chronic intestinal diseases.Entities:
Keywords: Celiac disease; Crohn's disease; Myofibroblast; Regulatory T cell; Smad
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Year: 2013 PMID： 24332927 DOI： 10.1016/j.cytogfr.2013.11.001
Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638