H Bouyarmane1, P Beaufils2, N Pujol3, J Bellemans4, S Roberts5, T Spalding6, S Zaffagnini7, M Marcacci7, P Verdonk8, M Womack9, R Verdonk10. 1. Service d'Orthopédie Traumatologie, Centre Hospitalier de Versailles, Université Versailles-Saint Quentin, rue de Versailles, 78150 Le Chesnay, France; Orthopaedic Surgery Center, 71, boulevard d'Anfa, Casablanca 20060, Morocco. 2. Service d'Orthopédie Traumatologie, Centre Hospitalier de Versailles, Université Versailles-Saint Quentin, rue de Versailles, 78150 Le Chesnay, France. Electronic address: pbeaufils@ch-versailles.fr. 3. Service d'Orthopédie Traumatologie, Centre Hospitalier de Versailles, Université Versailles-Saint Quentin, rue de Versailles, 78150 Le Chesnay, France. 4. Catholic University Hospitals, Langdorp, Belgium. 5. Orthopaedic Hospital, Oswestry, United Kingdom. 6. University Hospitals, Coventry, United Kingdom. 7. Istituto Ortopedico Rizzoli, Bologna, Italy. 8. Antwerpen Orthopaedic center, Antwerp, Belgium. 9. Orteq Sports Medicine, London, United Kingdom. 10. Ghent University Hospital, Ghent, Belgium.
Abstract
BACKGROUND: Segmental tissue loss in the lateral meniscus is associated with pain and increased risk of osteoarthritis even when indications have been carefully considered. HYPOTHESIS: Repairing the defect using a novel biodegradable scaffold will reduce pain and restore the knee function. METHODS: In this prospective multicenter study, a total of 54 patients (37 males/17 females; mean age: 28 years [16-50]) were enrolled. All patients presented with postmeniscectomy syndrome and segmental lateral meniscus loss, and were treated with a polyurethane biodegradable scaffold (Actifit(®), Orteq) implanted arthroscopically. Clinical outcomes were assessed at 6, 12 and 24 months using Visual Analogue Scale (VAS), International Knee Documentation Committee Score (IKDC) and Knee Injury and Osteoarthritis Outcome Score (KOOS). RESULTS: VAS decreased from 5.5 at baseline to 3.6 at 6 months, 3.4 at 12 months and 2.9 at 24 months. IKDC improved from 47.0 at baseline to 60.2, 67.0 and 67.0 at 6, 12 and 24 months. All KOOS subscores improved between baseline and 24 months. DISCUSSION: Clinical results of this study demonstrate clinically and statistically significant improvements of pain and function scores (VAS, IKDC, and all KOOS subscales except sport), at the 6 months follow-up and on all clinical outcomes at the 2-year follow-up. The Actifit(®) scaffold is safe and effective in treating lateral meniscus defects. LEVEL OF EVIDENCE IV: continuous prospective multicenter study.
BACKGROUND: Segmental tissue loss in the lateral meniscus is associated with pain and increased risk of osteoarthritis even when indications have been carefully considered. HYPOTHESIS: Repairing the defect using a novel biodegradable scaffold will reduce pain and restore the knee function. METHODS: In this prospective multicenter study, a total of 54 patients (37 males/17 females; mean age: 28 years [16-50]) were enrolled. All patients presented with postmeniscectomy syndrome and segmental lateral meniscus loss, and were treated with a polyurethane biodegradable scaffold (Actifit(®), Orteq) implanted arthroscopically. Clinical outcomes were assessed at 6, 12 and 24 months using Visual Analogue Scale (VAS), International Knee Documentation Committee Score (IKDC) and Knee Injury and Osteoarthritis Outcome Score (KOOS). RESULTS: VAS decreased from 5.5 at baseline to 3.6 at 6 months, 3.4 at 12 months and 2.9 at 24 months. IKDC improved from 47.0 at baseline to 60.2, 67.0 and 67.0 at 6, 12 and 24 months. All KOOS subscores improved between baseline and 24 months. DISCUSSION: Clinical results of this study demonstrate clinically and statistically significant improvements of pain and function scores (VAS, IKDC, and all KOOS subscales except sport), at the 6 months follow-up and on all clinical outcomes at the 2-year follow-up. The Actifit(®) scaffold is safe and effective in treating lateral meniscus defects. LEVEL OF EVIDENCE IV: continuous prospective multicenter study.
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