Isselmou Abdelhamid1, Khaled Lasram2, Ghlana Meiloud3, Nizar Ben Halim2, Rym Kefi2, Abdoulaye Samb4, Sonia Abdelhak2, Ahmed Houmeida5. 1. Centre Hospitalier National, B.P. 4160, Nouakchott, Mauritania. 2. LR11IPT05, Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis, Tunisia. 3. Laboratoire de Biochimie et Biologie Moléculaire, Faculté des Sciences et Techniques, B.P. 5026, Nouakchott, Mauritania. 4. Département de Chimie Biologique, UCAD, Dakar, Senegal. 5. Laboratoire de Biochimie et Biologie Moléculaire, Faculté des Sciences et Techniques, B.P. 5026, Nouakchott, Mauritania. Electronic address: houmeida@hotmail.com.
Abstract
AIMS: Many genetic association studies reported the contribution of KCNJ11 gene to type 2 diabetes susceptibility in different populations. We aimed to evaluate the association between E23K variant of KCNJ11 and type 2 diabetes in the Mauritanian population. MATERIALS AND METHODS: We performed a case-control association study including 135 type 2 diabetes Mauritanian patients and 135 controls. Genotyping for the E23K variant was performed using a TaqMan allelic discrimination assay. RESULTS: We found significant association between KCNJ11 E23K variant and type 2 diabetes (Global model, OR=2.08, 95% CI=1.09-3.97, p=0.026). In the Moor ethnic group, E23K was also associated with type 2 diabetes in the general model (OR=2.08, 95% CI=1.09-3.97, p=0.026) and under the dominant model (OR=2.49, 95% CI=1.12-5.55, p=0.026). In the Mauritanians of African descent, KK genotype was not found. Besides, E23K variant was not associated with type 2 diabetes (OR=0.69, 95% CI=0.04-11.32, p=0.793). CONCLUSIONS: Our results revealed the risk of type 2 diabetes conferred by KCNJ11 E23K gene variant in the Mauritanian population.
AIMS: Many genetic association studies reported the contribution of KCNJ11 gene to type 2 diabetes susceptibility in different populations. We aimed to evaluate the association between E23K variant of KCNJ11 and type 2 diabetes in the Mauritanian population. MATERIALS AND METHODS: We performed a case-control association study including 135 type 2 diabetes Mauritanianpatients and 135 controls. Genotyping for the E23K variant was performed using a TaqMan allelic discrimination assay. RESULTS: We found significant association between KCNJ11E23K variant and type 2 diabetes (Global model, OR=2.08, 95% CI=1.09-3.97, p=0.026). In the Moor ethnic group, E23K was also associated with type 2 diabetes in the general model (OR=2.08, 95% CI=1.09-3.97, p=0.026) and under the dominant model (OR=2.49, 95% CI=1.12-5.55, p=0.026). In the Mauritanians of African descent, KK genotype was not found. Besides, E23K variant was not associated with type 2 diabetes (OR=0.69, 95% CI=0.04-11.32, p=0.793). CONCLUSIONS: Our results revealed the risk of type 2 diabetes conferred by KCNJ11E23K gene variant in the Mauritanian population.