| Literature DB >> 24332491 |
Ming Yu1, Jian Ken Zhang2, Yingcai Wang2, Jiang Zhu2, Frank Kayser2, Julio C Medina2, Karen Siegler3, Marion Conn3, Bei Shan3, Mark P Grillo4, Peter Coward3, Jiwen Jim Liu2.
Abstract
The discovery and optimization of novel N-(3-(1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yloxy)phenyl)benzenesulfonamide GPR119 agonists is described. Modification of the pyridylphthalimide motif of the molecule with R(1)=-Me and R(2)=-(i)Pr substituents, incorporated with a 6-fluoro substitution on the central phenyl ring offered a potent and metabolically stable tool compound 22.Entities:
Keywords: Agonist; GPR119; Type 2 diabetes
Mesh：
Substances：
Year: 2013 PMID： 24332491 DOI： 10.1016/j.bmcl.2013.11.053
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823