WeiGe Wang1, Ying Cai1, WeiQi Sheng2, HongFen Lu2, XiaoQiu Li3. 1. Graduate student, Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Graduate student, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 2. Associate Professor, Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Associate Professor, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 3. Associate Professor, Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Associate Professor, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: leexiaoqiu@hotmail.com.
Abstract
OBJECTIVE: To retrospectively investigate the clinicopathologic spectrum of primary mucosal CD30-positive T-cell lymphoproliferative disorders (PTCLDs) of the head and neck. STUDY DESIGN: Archives of PTCLDs primarily arising in head and neck mucosa were reviewed. Immunostaining of CD20, CD3, CD4, CD8, CD30, CD56, anaplastic lymphoma kinase (ALK), epithelial membrane antigen (EMA), cytotoxic molecules (TIA-1, granzyme B, or perforin), and Ki67; in situ hybridization for Epstein-Barr virus; and T-cell receptor gene rearrangement analysis were performed. RESULTS: Fourteen cases of primary mucosal anaplastic large cell lymphoma (M-ALCL) were identified, and no lymphomatoid papulosis (LyP) cases were found. All cases demonstrated atypical mononuclear neoplastic cells with diverse histology and cytomorphology. The typical immunophenotype of neoplastic cells was CD3-positive, CD4-positive, CD8-negative, CD30-positive, ALK-negative, and cytotoxic molecules-positive. Infiltration of inflammatory cells was common. All cases presented an indolent course, regardless of therapy. CONCLUSIONS: PTCLDs of the head and neck provisionally included M-ALCL alone.
OBJECTIVE: To retrospectively investigate the clinicopathologic spectrum of primary mucosal CD30-positive T-cell lymphoproliferative disorders (PTCLDs) of the head and neck. STUDY DESIGN: Archives of PTCLDs primarily arising in head and neck mucosa were reviewed. Immunostaining of CD20, CD3, CD4, CD8, CD30, CD56, anaplastic lymphoma kinase (ALK), epithelial membrane antigen (EMA), cytotoxic molecules (TIA-1, granzyme B, or perforin), and Ki67; in situ hybridization for Epstein-Barr virus; and T-cell receptor gene rearrangement analysis were performed. RESULTS: Fourteen cases of primary mucosal anaplastic large cell lymphoma (M-ALCL) were identified, and no lymphomatoid papulosis (LyP) cases were found. All cases demonstrated atypical mononuclear neoplastic cells with diverse histology and cytomorphology. The typical immunophenotype of neoplastic cells was CD3-positive, CD4-positive, CD8-negative, CD30-positive, ALK-negative, and cytotoxic molecules-positive. Infiltration of inflammatory cells was common. All cases presented an indolent course, regardless of therapy. CONCLUSIONS: PTCLDs of the head and neck provisionally included M-ALCL alone.
Authors: Bruno Augusto Benevenuto de Andrade; Maria Danielle Fontes; Ana Luiza Oliveira Corrêa Roza; Pablo Agustin Vargas; Michelle Agostini; Nathalie Henriques Silva Canedo; Denize D'Azambuja Ramos; José Carlos Morais; Cristiane Bedran Milito; Mário José Romañach Journal: Head Neck Pathol Date: 2020-05-21