Zeynep Fatma Zor1, Berrin Isik2, Sedat Cetiner3. 1. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey. Electronic address: fatmazor@gazi.edu.tr. 2. Associate Professor, Anesthesiology and Reanimation Specialist, Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Ankara, Turkey. 3. Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey.
Abstract
OBJECTIVE:Pain is the most encountered complication following third molar surgery. Although nonsteroidal anti-inflammatory drugs are often used for pain control, the effect of preemptive lornoxicam has not been detailed. We compare the analgesic efficacy of preemptive lornoxicam versus postoperative lornoxicam. STUDY DESIGN:Forty-three participants aged 18 to 33 years who had bilateral, symmetrical third molars were included in this double-blind, randomized, placebo-controlled study. All participants took part in each of the 2 groups for a 1-month interval (crossover design). Group Pre received lornoxicam 8 mg intravenously 25 minutes before surgery and 2 mL serum saline postoperatively. Group Post was given the opposite protocol. Pain was evaluated by visual analog scale in the first 12 hours. RESULTS: We observed statistically significant differences in the reduction of the pain level in group Pre (P < .05). These participants felt less pain in the first 5 postoperative hours and needed fewer analgesics in the first 12 postoperative hours. CONCLUSIONS:Preemptive lornoxicam is effective for postoperative pain control.
RCT Entities:
OBJECTIVE:Pain is the most encountered complication following third molar surgery. Although nonsteroidal anti-inflammatory drugs are often used for pain control, the effect of preemptive lornoxicam has not been detailed. We compare the analgesic efficacy of preemptive lornoxicam versus postoperative lornoxicam. STUDY DESIGN: Forty-three participants aged 18 to 33 years who had bilateral, symmetrical third molars were included in this double-blind, randomized, placebo-controlled study. All participants took part in each of the 2 groups for a 1-month interval (crossover design). Group Pre received lornoxicam 8 mg intravenously 25 minutes before surgery and 2 mL serum saline postoperatively. Group Post was given the opposite protocol. Pain was evaluated by visual analog scale in the first 12 hours. RESULTS: We observed statistically significant differences in the reduction of the pain level in group Pre (P < .05). These participants felt less pain in the first 5 postoperative hours and needed fewer analgesics in the first 12 postoperative hours. CONCLUSIONS: Preemptive lornoxicam is effective for postoperative pain control.
Authors: Brett Doleman; Jo Leonardi-Bee; Thomas P Heinink; Hannah Boyd-Carson; Laura Carrick; Rahil Mandalia; Jon N Lund; John P Williams Journal: Cochrane Database Syst Rev Date: 2021-06-14