Vanessa L Gates1, Karen G Marshall2, Krystina Salzig2, Melissa Williams2, Robert J Lewandowski2, Riad Salem3. 1. Department of Radiology, Section of Nuclear Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 676 North St Clair, Suite 800, Chicago, IL 60611. 2. Section of Interventional Radiology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 676 North St Clair, Suite 800, Chicago, IL 60611. 3. Section of Interventional Radiology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 676 North St Clair, Suite 800, Chicago, IL 60611. Electronic address: r-salem@northwestern.edu.
Abstract
PURPOSE: To investigate the feasibility of yttrium-90 ((90)Y) glass microsphere radioembolization (including angiography, lung shunt assessment, and treatment) as a single-session, outpatient procedure. MATERIALS AND METHODS: Between January 2008 and June 2013, 14 patients underwent outpatient, single-session radioembolization with (90)Y glass microspheres. As part of the routine diagnostic work-up, all patients underwent either computed tomography (CT) or magnetic resonance imaging of the liver with three-dimensional analysis and had laboratory results forwarded to our center for confirmation of candidacy before treatment. On treatment day, all patients underwent planning mesenteric angiography with flat panel cone-beam CT imaging. Patients were administered 33-85 MBq of technetium-99m macroaggregated albumin ((99m)Tc-MAA) via a microcatheter positioned in a hepatic artery supplying the tumor of interest. Planar scintigraphy was initiated within 2 hours after the administration of (99m)Tc-MAA and lung shunt fraction was determined. Final dosimetry calculations were performed while the patient was being transferred back from nuclear medicine to interventional radiology. RESULTS: All patients successfully underwent planning angiography with administration of (99m)Tc-MAA and (90)Y radioembolization as a single-session treatment. There were no reportable or recordable medical events; treatment was carried out to the desired dose in all cases. The mean total procedure time was 2.70 hours ± 0.72 (range, 1.63-3.97 h). CONCLUSIONS: This study reports a novel proof of concept for performing radioembolization in a single-session setting. By using the described method, time between initial clinical assessments and radioembolization treatment is decreased, and costs are minimized.
PURPOSE: To investigate the feasibility of yttrium-90 ((90)Y) glass microsphere radioembolization (including angiography, lung shunt assessment, and treatment) as a single-session, outpatient procedure. MATERIALS AND METHODS: Between January 2008 and June 2013, 14 patients underwent outpatient, single-session radioembolization with (90)Y glass microspheres. As part of the routine diagnostic work-up, all patients underwent either computed tomography (CT) or magnetic resonance imaging of the liver with three-dimensional analysis and had laboratory results forwarded to our center for confirmation of candidacy before treatment. On treatment day, all patients underwent planning mesenteric angiography with flat panel cone-beam CT imaging. Patients were administered 33-85 MBq of technetium-99m macroaggregated albumin ((99m)Tc-MAA) via a microcatheter positioned in a hepatic artery supplying the tumor of interest. Planar scintigraphy was initiated within 2 hours after the administration of (99m)Tc-MAA and lung shunt fraction was determined. Final dosimetry calculations were performed while the patient was being transferred back from nuclear medicine to interventional radiology. RESULTS: All patients successfully underwent planning angiography with administration of (99m)Tc-MAA and (90)Y radioembolization as a single-session treatment. There were no reportable or recordable medical events; treatment was carried out to the desired dose in all cases. The mean total procedure time was 2.70 hours ± 0.72 (range, 1.63-3.97 h). CONCLUSIONS: This study reports a novel proof of concept for performing radioembolization in a single-session setting. By using the described method, time between initial clinical assessments and radioembolization treatment is decreased, and costs are minimized.
Authors: Robert J Lewandowski; Khairuddin Memon; Mary F Mulcahy; Ryan Hickey; Karen Marshall; Melissa Williams; Krystina Salzig; Vanessa L Gates; Bassel Atassi; Michael Vouche; Rohi Atassi; Kush Desai; Elias Hohlastos; Kent Sato; Ali Habib; Sheetal Kircher; Steven B Newman; Halla Nimeiri; Al B Benson; Riad Salem Journal: Eur J Nucl Med Mol Imaging Date: 2014-06-07 Impact factor: 9.236
Authors: Ahmed Gabr; Joseph Ralph Kallini; Vanessa L Gates; Ryan Hickey; Laura Kulik; Kush Desai; Bartley Thornburg; Karen Marshall; Krystina Salzig; Melissa Williams; Carlene Del Castillo; Daniel Ganger; Elias Hohlastos; Talia Baker; Robert J Lewandowski; Riad Salem Journal: Eur J Nucl Med Mol Imaging Date: 2016-06-17 Impact factor: 9.236
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Authors: Arthur J A T Braat; Julia E Huijbregts; I Quintus Molenaar; Inne H M Borel Rinkes; Maurice A A J van den Bosch; Marnix G E H Lam Journal: Front Oncol Date: 2014-07-30 Impact factor: 6.244
Authors: Jens M Theysohn; Marcus Ruhlmann; Stefan Müller; Alexander Dechene; Jan Best; Johannes Haubold; Lale Umutlu; Guido Gerken; Andreas Bockisch; Thomas C Lauenstein Journal: PLoS One Date: 2015-09-03 Impact factor: 3.240