| Literature DB >> 24332042 |
Lianjie Li1, Chuan Shen1, Eijiro Nakamura1, Kiyohiro Ando1, Sabina Signoretti2, Rameen Beroukhim3, Glenn S Cowley4, Patrick Lizotte4, Ella Liberzon5, Steven Bair1, David E Root4, Pablo Tamayo4, Aviad Tsherniak4, Su-Chun Cheng6, Barbara Tabak7, Anders Jacobsen8, A Ari Hakimi9, Nikolaus Schultz8, Giovanni Ciriello8, Chris Sander8, James J Hsieh10, William G Kaelin11.
Abstract
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer and is often linked to loss of chromosome 3p, which harbors the VHL tumor suppressor gene, loss of chromosome 14q, which includes HIF1A, and gain of chromosome 5q. The relevant target(s) on chromosome 5q is not known. Here, we show that 5q amplification leads to overexpression of the SQSTM1 oncogene in ccRCC lines and tumors. Overexpression of SQSTM1 in ccRCC lines promoted resistance to redox stress and increased soft agar growth, while downregulation of SQSTM1 decreased resistance to redox stress, impaired cellular fitness, and decreased tumor formation. Therefore, the selection pressure to amplify 5q in ccRCC is driven, at least partly, by SQSTM1.Entities:
Mesh：
Substances：
Year: 2013 PMID： 24332042 PMCID： PMC3910168 DOI： 10.1016/j.ccr.2013.10.025
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743