Literature DB >> 24332024

cGAS dimerization entangles DNA recognition.

Philip J Kranzusch1, Russell E Vance2.   

Abstract

Detection of foreign DNA in the cell cytosol triggers potent antiviral responses. In this issue of Immunity, Li et al. (2013) provide new structural and biochemical data indicating that a cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is activated by DNA-induced dimerization.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 24332024     DOI： 10.1016/j.immuni.2013.11.012

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  9 in total

1.  PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.

Authors:  Janna Seifried; Stephen Soonthornvacharin; Sunnie M Yoh; Monika Schneider; Rana E Akleh; Kevin C Olivieri; Paul D De Jesus; Chunhai Ruan; Elisa de Castro; Pedro A Ruiz; David Germanaud; Vincent des Portes; Adolfo García-Sastre; Renate König; Sumit K Chanda
Journal:  Cell       Date:  2015-06-04       Impact factor: 41.582

Review 2.  Multifaceted roles of TRIM38 in innate immune and inflammatory responses.

Authors:  Ming-Ming Hu; Hong-Bing Shu
Journal:  Cell Mol Immunol       Date:  2017-02-13       Impact factor: 11.530

3.  cGAS is activated by DNA in a length-dependent manner.

Authors:  Stefanie Luecke; Andreas Holleufer; Maria H Christensen; Kasper L Jønsson; Gerardo A Boni; Lambert K Sørensen; Mogens Johannsen; Martin R Jakobsen; Rune Hartmann; Søren R Paludan
Journal:  EMBO Rep       Date:  2017-08-10       Impact factor: 8.807

4.  Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase.

Authors:  Salim Abdisalaam; Souparno Bhattacharya; Shibani Mukherjee; Debapriya Sinha; Kalayarasan Srinivasan; Mingrui Zhu; Esra A Akbay; Hesham A Sadek; Jerry W Shay; Aroumougame Asaithamby
Journal:  J Biol Chem       Date:  2020-06-15       Impact factor: 5.157

Review 5.  The mechanism of double-stranded DNA sensing through the cGAS-STING pathway.

Authors:  Chang Shu; Xin Li; Pingwei Li
Journal:  Cytokine Growth Factor Rev       Date:  2014-06-22       Impact factor: 7.638

6.  SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing.

Authors:  Ye Cui; Huansha Yu; Xin Zheng; Rui Peng; Qiang Wang; Yi Zhou; Rui Wang; Jiehua Wang; Bo Qu; Nan Shen; Qiang Guo; Xing Liu; Chen Wang
Journal:  PLoS Pathog       Date:  2017-01-17       Impact factor: 6.823

7.  Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion.

Authors:  Priya Luthra; Sebastian Aguirre; Benjamin C Yen; Colette A Pietzsch; Maria T Sanchez-Aparicio; Bersabeh Tigabu; Lorraine K Morlock; Adolfo García-Sastre; Daisy W Leung; Noelle S Williams; Ana Fernandez-Sesma; Alexander Bukreyev; Christopher F Basler
Journal:  mBio       Date:  2017-04-04       Impact factor: 7.867

8.  Catalytic Promiscuity of cGAS: A Facile Enzymatic Synthesis of 2'-3'-Linked Cyclic Dinucleotides.

Authors:  Katrin Rosenthal; Martin Becker; Jascha Rolf; Regine Siedentop; Michael Hillen; Markus Nett; Stephan Lütz
Journal:  Chembiochem       Date:  2020-08-04       Impact factor: 3.164

Review 9.  Cytosolic DNA sensing by cGAS: regulation, function, and human diseases.

Authors:  Le Yu; Pengda Liu
Journal:  Signal Transduct Target Ther       Date:  2021-04-30
  9 in total

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