Hyoung Yoon Chang1, Katherine M Keyes2, Kyung-Sook Lee3, In Ae Choi4, Se Joo Kim5, Kyung Won Kim6, Youn Ho Shin7, Kang Mo Ahn8, Soo-Jong Hong9, Yee-Jin Shin10. 1. Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Epidemiology, Columbia University Mailman School of Public Health, NY, USA. 2. Department of Epidemiology, Columbia University Mailman School of Public Health, NY, USA. 3. Department of Rehabilitation, Hanshin University, Gyeonggi-do, Republic of Korea. 4. Sewon Infant Child Development Center, Seoul, Republic of Korea. 5. Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea; Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. 6. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. 7. Department of Pediatrics, CHA Medical Center, Pochon CHA University College of Medicine, Seoul, Republic of Korea. 8. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 9. Department of Pediatrics, Childhood Asthma Atopy Center, Research Center for Standardization of Allergic Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: sjhong@amc.seoul.kr. 10. Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: yjshin@yuhs.ac.
Abstract
BACKGROUND: Maternal prenatal depression is associated with lower offspring birth weight, yet the impact of gestational age on this association remains inadequately understood. AIMS: We aimed to investigate the effect of prenatal depression on low birth weight, gestational age, and weight for gestational age at term. STUDY DESIGN: Prospective cohort study. SUBJECT: Data were collected from 691 women in their third trimester of pregnancy who went on to give birth to a singleton at term without perinatal complications. One hundred and fifty-two women had a Center for Epidemiologic Studies Depression Scale-10 score ≥10 and were classed as prenatally depressed. OUTCOME MEASURES: Low birth weight (<2500g), gestational age at birth, and birth weight percentile for gestational age. RESULTS: Offspring of prenatally depressed women were more likely to be low birth weight (Odds ratio [OR] 2.94, 95% confidence interval [CI] 1.14-7.58) than offspring of prenatally non-depressed women, but the association was attenuated (OR 1.66, 95% CI 0.55-5.02) when adjusted for gestational age. Offspring of prenatally depressed women had lower gestational age in weeks (OR for one week increase in gestational age: 0.66, 95% CI 0.47-0.93) than offspring of prenatally non-depressed women. There was no association between prenatal depression and birth weight percentile for gestational age. CONCLUSIONS: Prenatal depression was not associated with low birth weight at term, but was associated with gestational age, suggesting that association between maternal depression and birth weight may be a reflection of the impact of depression on offspring gestational age.
BACKGROUND: Maternal prenatal depression is associated with lower offspring birth weight, yet the impact of gestational age on this association remains inadequately understood. AIMS: We aimed to investigate the effect of prenatal depression on low birth weight, gestational age, and weight for gestational age at term. STUDY DESIGN: Prospective cohort study. SUBJECT: Data were collected from 691 women in their third trimester of pregnancy who went on to give birth to a singleton at term without perinatal complications. One hundred and fifty-two women had a Center for Epidemiologic Studies Depression Scale-10 score ≥10 and were classed as prenatally depressed. OUTCOME MEASURES: Low birth weight (<2500g), gestational age at birth, and birth weight percentile for gestational age. RESULTS: Offspring of prenatally depressed women were more likely to be low birth weight (Odds ratio [OR] 2.94, 95% confidence interval [CI] 1.14-7.58) than offspring of prenatally non-depressed women, but the association was attenuated (OR 1.66, 95% CI 0.55-5.02) when adjusted for gestational age. Offspring of prenatally depressed women had lower gestational age in weeks (OR for one week increase in gestational age: 0.66, 95% CI 0.47-0.93) than offspring of prenatally non-depressed women. There was no association between prenatal depression and birth weight percentile for gestational age. CONCLUSIONS:Prenatal depression was not associated with low birth weight at term, but was associated with gestational age, suggesting that association between maternal depression and birth weight may be a reflection of the impact of depression on offspring gestational age.
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