Daiji Nagayama1, Kei Endo1, Masahiro Ohira1, Takashi Yamaguchi1, Noriko Ban1, Hidetoshi Kawana1, Ayako Nagumo1, Atsuhito Saiki2, Tomokazu Oyama1, Yoh Miyashita1, Kohji Shirai3. 1. Center of Diabetes, Endocrine and Metabolism, Toho University Medical Center Sakura Hospital, Chiba 285-8741, Japan. 2. Center of Diabetes, Endocrine and Metabolism, Toho University Medical Center Sakura Hospital, Chiba 285-8741, Japan. Electronic address:atsuhito156@sakura.med.toho-u.ac.jp. 3. Department of Internal Medicine, Toho University Medical Center Sakura Hospital, Chiba 285-8741, Japan.
Abstract
OBJECTIVE: Obesity is associated with type 2 diabetes, dyslipidemia and hypertension, contributing to atherogenesis. Weight reduction is the fundamental therapy for obesity. Recently, a novel arterial stiffness parameter called cardio-ankle vascular index (CAVI) has been developed. We hypothesized that CAVI may be a candidate marker of increased vascular stiffness in obese patients. The aim of this study is to investigate the effect of weight reduction on CAVI. SUBJECTS AND METHODS: Using CAVI as an indicator, we assessed the changes in arterial stiffness in 47 obese Japanese subjects (aged 46 ± 13 years) who underwent a 12-week weight reduction program consisting of a calorie restriction diet (20-25 kcal/day) and exercise therapy. Visceral fat area (VFA) was evaluated by CT. RESULTS: At baseline, CAVI correlated positively with age (r = 0.70), blood pressure (r = 0.23), VFA (r = 0.26) and HbA1c (r = 0.39). After 12 weeks of weight reduction, mean BMI decreased from 33.3 ± 7.5 to 30.7 ± 6.4 kg/m(2) (p < 0.0001), and mean CAVI decreased from 8.3 to 7.9 (p < 0.01). The change in VFA correlated positively with change in CAVI in subjects with decrease in CAVI (r = 0.47). Furthermore, change in VFA was a significant independent predictor for change in CAVI. No significant correlation was observed between change in CAVI and clinical variables such as BMI, HbA1c and lipids. CONCLUSION: This study demonstrated that CAVI decreased after weight reduction, and was associated with a decrease in VFA. CAVI reduction maybe a marker of improved vascular stiffness after weight reduction in subjects with visceral adiposity. Â
OBJECTIVE:Obesity is associated with type 2 diabetes, dyslipidemia and hypertension, contributing to atherogenesis. Weight reduction is the fundamental therapy for obesity. Recently, a novel arterial stiffness parameter called cardio-ankle vascular index (CAVI) has been developed. We hypothesized that CAVI may be a candidate marker of increased vascular stiffness in obesepatients. The aim of this study is to investigate the effect of weight reduction on CAVI. SUBJECTS AND METHODS: Using CAVI as an indicator, we assessed the changes in arterial stiffness in 47 obese Japanese subjects (aged 46 ± 13 years) who underwent a 12-week weight reduction program consisting of a calorie restriction diet (20-25 kcal/day) and exercise therapy. Visceral fat area (VFA) was evaluated by CT. RESULTS: At baseline, CAVI correlated positively with age (r = 0.70), blood pressure (r = 0.23), VFA (r = 0.26) and HbA1c (r = 0.39). After 12 weeks of weight reduction, mean BMI decreased from 33.3 ± 7.5 to 30.7 ± 6.4 kg/m(2) (p < 0.0001), and mean CAVI decreased from 8.3 to 7.9 (p < 0.01). The change in VFA correlated positively with change in CAVI in subjects with decrease in CAVI (r = 0.47). Furthermore, change in VFA was a significant independent predictor for change in CAVI. No significant correlation was observed between change in CAVI and clinical variables such as BMI, HbA1c and lipids. CONCLUSION: This study demonstrated that CAVI decreased after weight reduction, and was associated with a decrease in VFA. CAVI reduction maybe a marker of improved vascular stiffness after weight reduction in subjects with visceral adiposity. Â
Authors: Matthew J Budoff; Bruce Alpert; Julio A Chirinos; Bo Fernhall; Naomi Hamburg; Kazuomi Kario; Iftikhar Kullo; Kunihiro Matsushita; Toru Miyoshi; Hirofumi Tanaka; Ray Townsend; Paul Valensi Journal: Am J Hypertens Date: 2022-05-10 Impact factor: 3.080