Literature DB >> 2433141

Paroxysmal neuronal depolarizations in the rat motorcortex in vivo: intracellular injection of the calcium agonist BAY K 8644.

J Walden, H Pockberger, E J Speckmann, H Petsche.   

Abstract

Epileptic activity was elicited in the rat's motor cortex by local application of penicillin. At the neuronal level it consisted of typical paroxysmal depolarization shifts. The calcium agonist BAY K 8644 was injected into neurons showing such a discharge pattern. The application of this drug increased amplitude and after depolarization of paroxysmal neuronal depolarizations.

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Year:  1986        PMID： 2433141     DOI： 10.1007/bf00340500

Source DB:  PubMed          Journal:  Exp Brain Res        ISSN： 0014-4819            Impact factor:   1.972


  12 in total

1.  Action of organic antagonists on neuronal calcium currents.

Authors:  W Boll; H D Lux
Journal:  Neurosci Lett       Date:  1985-05-23       Impact factor: 3.046

2.  Excitability changes and inhibitory mechanisms in neocortical neurons during seizures.

Authors:  G F Ayala; H Matsumoto; R J Gumnit
Journal:  J Neurophysiol       Date:  1970-01       Impact factor: 2.714

3.  [Paroxysmal depolarisation of the soma and axonic discharge of the same neuron treated with metrazol (autoactive neurons in Helix)].

Authors:  C Ducreux; H Takeuchi; N Chalazonitis
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1972-10-23

4.  The depolarization shift in "epileptic" neurons.

Authors:  D A Prince
Journal:  Exp Neurol       Date:  1968-08       Impact factor: 5.330

5.  Topical application of penicillin into hippocampal in vitro slices: A methodological study using benzyl (14C) penicillin.

Authors:  S Olofsson; P A Ridderheim; H Silfvenius
Journal:  Acta Physiol Scand       Date:  1980-05

6.  Dendritic mechanisms underlying penicillin-induced epileptiform activity.

Authors:  R K Wong; D A Prince
Journal:  Science       Date:  1979-06-15       Impact factor: 47.728

7.  Mechanisms of neocortical epileptogenesis in vitro.

Authors:  M J Gutnick; B W Connors; D A Prince
Journal:  J Neurophysiol       Date:  1982-12       Impact factor: 2.714

8.  Calcium-dependent inward current in Aplysia bursting pace-maker neurones.

Authors:  R H Kramer; R S Zucker
Journal:  J Physiol       Date:  1985-05       Impact factor: 5.182

9.  Suppression of focal epileptiform discharges by intraventricular perfusion of a calcium antagonist.

Authors:  J Walden; E J Speckmann; O W Witte
Journal:  Electroencephalogr Clin Neurophysiol       Date:  1985-10

10.  Motor cortical epileptic foci in vivo: actions of a calcium channel blocker on paroxysmal neuronal depolarizations.

Authors:  O W Witte; E J Speckmann; J Walden
Journal:  Electroencephalogr Clin Neurophysiol       Date:  1987-01
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  3 in total

1.  Specific suppression of pentylenetetrazol-induced epileptiform discharges in CA3 neurons (hippocampal slice, guinea pig) by the organic calcium antagonists flunarizine and verapamil.

Authors:  D Bingmann; E J Speckmann
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

2.  Spontaneous and stimulus-triggered epileptic discharges: delayed antiepileptic effect with triggering.

Authors:  R Köhling; H Straub; E J Speckmann
Journal:  Exp Brain Res       Date:  1994       Impact factor: 1.972

Review 3.  The Paroxysmal Depolarization Shift: Reconsidering Its Role in Epilepsy, Epileptogenesis and Beyond.

Authors:  Helmut Kubista; Stefan Boehm; Matej Hotka
Journal:  Int J Mol Sci       Date:  2019-01-29       Impact factor: 5.923
  3 in total

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