BACKGROUND: The expression of serum angiogenic factors has been associated with tumor dissemination and poor prognosis in multiple cancer types. However, it is still unclear whether these angiogenic molecules can be used as an independent molecular marker or in correlation with other parameters for predicting the prognosis of colorectal carcinoma (CRC)patients. METHODS: Protein expression was evaluated in 28 CRC and 10 control cases using Angiogenesis Fast Quant technology. RESULTS: In this study, we found downregulation of PDGF-bb protein expression in the serum of patients with colorectal cancer compared with the control group. Thus, PDGF-bb might play an essential function in the progression of CRC. CONCLUSIONS: Our study indicated that the PDGF-bb protein expression might be an independent prognostic marker or in association with other parameters for CRC patients. Celsius.
BACKGROUND: The expression of serum angiogenic factors has been associated with tumor dissemination and poor prognosis in multiple cancer types. However, it is still unclear whether these angiogenic molecules can be used as an independent molecular marker or in correlation with other parameters for predicting the prognosis of colorectal carcinoma (CRC)patients. METHODS: Protein expression was evaluated in 28 CRC and 10 control cases using Angiogenesis Fast Quant technology. RESULTS: In this study, we found downregulation of PDGF-bb protein expression in the serum of patients with colorectal cancer compared with the control group. Thus, PDGF-bb might play an essential function in the progression of CRC. CONCLUSIONS: Our study indicated that the PDGF-bb protein expression might be an independent prognostic marker or in association with other parameters for CRCpatients. Celsius.
Authors: Nkechiyere G Nwani; Maria L Deguiz; Benilde Jimenez; Elena Vinokour; Oleksii Dubrovskyi; Andrey Ugolkov; Andrew P Mazar; Olga V Volpert Journal: Cancer Res Date: 2016-02-26 Impact factor: 12.701
Authors: Romana Moench; Martin Gasser; Karol Nawalaniec; Tanja Grimmig; Amrendra K Ajay; Larissa Camila Ribeiro de Souza; Minghua Cao; Yueming Luo; Petra Hoegger; Carmen M Ribas; Jurandir M Ribas-Filho; Osvaldo Malafaia; Reinhard Lissner; Li-Li Hsiao; Ana Maria Waaga-Gasser Journal: Oncotarget Date: 2022-10-19
Authors: Alexandra Iulia Irimie; Cornelia Braicu; Roxana Cojocneanu; Lorand Magdo; Anca Onaciu; Cristina Ciocan; Nikolay Mehterov; Diana Dudea; Smaranda Buduru; Ioana Berindan-Neagoe Journal: Int J Environ Res Public Health Date: 2018-07-23 Impact factor: 3.390