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Literature DB >> 24330136

Guidelines for optimizing design and analysis of clinical studies of nutrient effects.

Abstract

Presented here is a system to standardize clinical studies of nutrient effects, using nutrient-specific physiological criteria. These guidelines are based mainly on analysis of the typical sigmoid curve of biological response to nutrients and are intended for design, interpretation, and pooling of studies of nutrient effects. Five rules have been articulated for individual studies of nutrients, and six for systematic reviews and/or meta-analyses.

Keywords: clinical studies; meta-analysis; nutrient effects; sigmoid curve; study design; systematic review

Mesh：

Year: 2013 PMID： 24330136 DOI： 10.1111/nure.12090

Source DB: PubMed Journal: Nutr Rev ISSN： 0029-6643 Impact factor: 7.110

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Cited

100 in total

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Authors: Hemant Goyal; Abhilash Perisetti; M Rubayat Rahman; Avi Levin; Giuseppe Lippi
Journal: Dig Dis Sci Date: 2018-12-03 Impact factor: 3.199

Review 2. Vitamin D administration during pregnancy as prevention for pregnancy, neonatal and postnatal complications.

Authors: Carol L Wagner; Bruce W Hollis; Kalliopi Kotsa; Hana Fakhoury; Spyridon N Karras
Journal: Rev Endocr Metab Disord Date: 2017-09 Impact factor: 6.514

3. The effects of vitamin D supplementation on proatherogenic inflammatory markers and carotid intima media thickness in subjects with metabolic syndrome: a randomized double-blind placebo-controlled clinical trial.

Authors: Shabnam Salekzamani; Abolhassan Shakeri Bavil; Hossein Mehralizadeh; Mohammad Asghari Jafarabadi; Aymaral Ghezel; Bahram Pourghassem Gargari
Journal: Endocrine Date: 2017-05-16 Impact factor: 3.633

4. Effect of high-dose vitamin D supplementation on cardiometabolic risk factors in subjects with metabolic syndrome: a randomized controlled double-blind clinical trial.

Authors: S Salekzamani; H Mehralizadeh; A Ghezel; Y Salekzamani; M A Jafarabadi; A S Bavil; B P Gargari
Journal: J Endocrinol Invest Date: 2016-07-11 Impact factor: 4.256

Guidelines for optimizing design and analysis of clinical studies of nutrient effects.

Review 1. Vitamin D and Gastrointestinal Cancers: A Narrative Review.

Review 2. Vitamin D administration during pregnancy as prevention for pregnancy, neonatal and postnatal complications.

3. The effects of vitamin D supplementation on proatherogenic inflammatory markers and carotid intima media thickness in subjects with metabolic syndrome: a randomized double-blind placebo-controlled clinical trial.

4. Effect of high-dose vitamin D supplementation on cardiometabolic risk factors in subjects with metabolic syndrome: a randomized controlled double-blind clinical trial.

5. Nutrition: vitamins on trial.

Review 6. Maternal vitamin D levels during pregnancy and neonatal health: evidence to date and clinical implications.

7. Vitamin D: Ten Beliefs.

8. Vitamin D and childhood asthma: causation and contribution to disease activity.

9. Vitamin D, leptin and impact on immune response to seasonal influenza A/H1N1 vaccine in older persons.

Review 10. "Let there be light": the role of vitamin D in the immune response to vaccines.