BACKGROUND: Pertussis is an important cause of infant death worldwide and continues to be a public health concern even in countries with high vaccination coverage. Severe (critical) pertussis with hyperleukocytosis is a severe form of the disease with up to 80% mortality rate. Attempts have been reported to reduce the white blood cell burden by exchange transfusion (ET) with conflicting conclusions. CASE REPORT: We report a case of critical pertussis in a neonate who was treated with ET, in view of a comprehensive literature review. RESULTS: The patient was discharged without any sequelae. CONCLUSION: ET should be considered in all infants suffering from critical pertussis and hyperleukocytosis, even in secondary care community hospitals.
BACKGROUND: Pertussis is an important cause of infantdeath worldwide and continues to be a public health concern even in countries with high vaccination coverage. Severe (critical) pertussis with hyperleukocytosis is a severe form of the disease with up to 80% mortality rate. Attempts have been reported to reduce the white blood cell burden by exchange transfusion (ET) with conflicting conclusions. CASE REPORT: We report a case of critical pertussis in a neonate who was treated with ET, in view of a comprehensive literature review. RESULTS: The patient was discharged without any sequelae. CONCLUSION: ET should be considered in all infants suffering from critical pertussis and hyperleukocytosis, even in secondary care community hospitals.
Authors: Susan E Wiedmeier; Timothy M Bahr; Robin K Ohls; Thomas R Christensen; Vickie L Baer; Sarah J Ilstrup; Kelly Cail; Robert D Christensen Journal: J Perinatol Date: 2020-07-15 Impact factor: 2.521
Authors: Guillaume Maitre; Damien Schaffner; Julia Natterer; David Longchamp; Thomas Ferry; Manuel Diezi; Stefano Di Bernardo; Marie-Hélène Perez; Vivianne Amiet Journal: Front Pediatr Date: 2018-09-26 Impact factor: 3.418