BACKGROUND: In recent years, pharmacogenetic algorithms were developed for estimating the appropriate dose of vitamin K antagonists. AIM: To evaluate the performance of new generation artificial neural networks (ANNs) to predict the warfarin maintenance dose. METHODS: Demographic, clinical and genetic data (CYP2C9 and VKORC1 polymorphisms) from 377 patients treated with warfarin were used. The final prediction model was based on 23 variables selected by TWIST® system within a bipartite division of the data set (training and testing) protocol. RESULTS: The ANN algorithm reached high accuracy, with an average absolute error of 5.7 mg of the warfarin maintenance dose. In the subset of patients requiring ≤21 mg and 21-49 mg (45 and 51% of the cohort, respectively) the absolute error was 3.86 mg and 5.45 with a high percentage of subjects being correctly identified (71 and 73%, respectively). CONCLUSION: ANN appears to be a promising tool for vitamin K antagonist maintenance dose prediction.
BACKGROUND: In recent years, pharmacogenetic algorithms were developed for estimating the appropriate dose of vitamin K antagonists. AIM: To evaluate the performance of new generation artificial neural networks (ANNs) to predict the warfarin maintenance dose. METHODS: Demographic, clinical and genetic data (CYP2C9 and VKORC1 polymorphisms) from 377 patients treated with warfarin were used. The final prediction model was based on 23 variables selected by TWIST® system within a bipartite division of the data set (training and testing) protocol. RESULTS: The ANN algorithm reached high accuracy, with an average absolute error of 5.7 mg of the warfarin maintenance dose. In the subset of patients requiring ≤21 mg and 21-49 mg (45 and 51% of the cohort, respectively) the absolute error was 3.86 mg and 5.45 with a high percentage of subjects being correctly identified (71 and 73%, respectively). CONCLUSION: ANN appears to be a promising tool for vitamin K antagonist maintenance dose prediction.
Authors: Tatjana Huebner; Michael Steffens; Roland Linder; Jochen Fracowiak; Daria Langner; Marco Garling; Felix Falkenberg; Christoph Roethlein; Willy Gomm; Britta Haenisch; Julia Stingl Journal: BMJ Open Date: 2020-04-27 Impact factor: 2.692
Authors: Ashkan Sharabiani; Edith A Nutescu; William L Galanter; Houshang Darabi Journal: Comput Math Methods Med Date: 2018-05-13 Impact factor: 2.238