[Characterisation of tear film dynamics after application of trehalose for treatment of dry eye].

The implementation of additional modalities for tear film break-up time characterisation expands the application range of the Oculus® Keratograph 5M. The aim of the present study was to evaluate the possibilities for non-invasive break-up time analysis using this device. Furthermore we applied the Oculus® Keratograph 5M to characterise possible modifications of tear break-up time after application of Thealoz® eye drops (Théa Pharma). The device allowed for a precise and solid topographical analysis of tear film dynamics. We could show that at four weeks after treatment, trehalose solution was a better treatment for dry eye compared with saline. These results are in agreement with our previous in vitro findings concerning the protective role of trehalose on desiccation-caused cell death in a corneal epithelial model. Georg Thieme Verlag KG Stuttgart · New York.