Peter Brand1, Marcus Bauer, Monika Gube, Klaus Lenz, Uwe Reisgen, Vilia Elena Spiegel-Ciobanu, Thomas Kraus. 1. From the Institute for Occupational and Social Medicine (Drs Brand, Bauer, Gube, and Kraus) and ISF-Welding and Joining Institute (Mr Lenz and Dr Reisgen), Aachen University of Technology, Aachen, Germany; and Institution for Statutory Accident Insurance and Prevention in the Woodworking and Metalworking Industry (Dr Spiegel-Ciobanu), Hannover, Germany.
Abstract
OBJECTIVES: It has been shown that exposure of subjects to emissions from a metal inert gas (MIG) brazing process of zinc-coated material led to an increase of high-sensitivity C-reactive protein (hsCRP) in the blood. In this study, the no-observed-effect level (NOEL) for such emissions was assessed. METHODS: Twelve healthy subjects were exposed for 6 hours to different concentrations of MIG brazing fumes under controlled conditions. High-sensitivity C-reactive protein was measured in the blood. RESULTS: For welding fumes containing 1.20 and 1.50 mg m zinc, high-sensitivity C-reactive protein was increased the day after exposure. For 0.90 mg m zinc, no increase was detected. CONCLUSIONS: These data indicate that the no-observed-effect level for emissions from a MIG brazing process of zinc-coated material in respect to systemic inflammation is found for welding fumes with zinc concentrations between 0.90 and 1.20 mg m.
OBJECTIVES: It has been shown that exposure of subjects to emissions from a metal inert gas (MIG) brazing process of zinc-coated material led to an increase of high-sensitivity C-reactive protein (hsCRP) in the blood. In this study, the no-observed-effect level (NOEL) for such emissions was assessed. METHODS: Twelve healthy subjects were exposed for 6 hours to different concentrations of MIG brazing fumes under controlled conditions. High-sensitivity C-reactive protein was measured in the blood. RESULTS: For welding fumes containing 1.20 and 1.50 mg m zinc, high-sensitivity C-reactive protein was increased the day after exposure. For 0.90 mg m zinc, no increase was detected. CONCLUSIONS: These data indicate that the no-observed-effect level for emissions from a MIG brazing process of zinc-coated material in respect to systemic inflammation is found for welding fumes with zinc concentrations between 0.90 and 1.20 mg m.
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