| Literature DB >> 24326672 |
Hélène Zéphir1, Corinne Gower-Rousseau2, Julia Salleron3, Olivier Simon4, Marc Debouverie5, Emmanuelle Le Page6, Yoram Bouhnik7, Christine Lebrun-Frenay8, Caroline Papeix9, Benoît Vigneron10, Matthieu Allez11, Lionel Prin12, Jacques Cosnes13, Patrick Vermersch14, Jean-Frédéric Colombel15.
Abstract
An association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) has been suggested. The purpose of this study was to compare the disease course of patients with both MS and IBD with that of patients with isolated MS or isolated IBD. Sixty-six MS-IBD patients were identified and were matched with 251 isolated MS and 257 isolated IBD controls. Main outcomes were scores using the Expanded Disability Status Scale (EDSS) in MS and extent of disease extension in IBD at last clinical evaluation. After a median 12 years of disease duration, the median EDSS and the percentages of patients reaching an EDSS of 3.0 and 4.0 were significantly lower in MS-IBD patients than in controls. MS had no impact on IBD. MS course appears to be milder in patients with concomitant IBD.Entities:
Keywords: Multiple sclerosis; colitis; epidemiology; prognosis
Mesh：
Year: 2013 PMID： 24326672 DOI： 10.1177/1352458513515081
Source DB: PubMed Journal: Mult Scler ISSN： 1352-4585 Impact factor: 6.312