Fleur Delva1, Sophie Auriacombe2, Luc Letenneur3, Alexandra Foubert-Samier1, Alain Bredin4, Anne Clementy5, Chrystelle Latxague6, Emmanuel Puymirat7, Guillaume Ballan8, Jean-Phillipe Delabrousse-Mayoux9, Laurent Glénisson10, Lise Mazat11, Umberto Spampinato12, Muriel Rainfray13, François Tison14, Jean-François Dartigues1. 1. Centre INSERM, ISPED, Bordeaux, France University Bordeaux Victor Segalen, Bordeaux, France CMRR d'Aquitaine, CHU de Bordeaux, Bordeaux, France. 2. CMRR d'Aquitaine, CHU de Bordeaux, Bordeaux, France. 3. Centre INSERM, ISPED, Bordeaux, France University Bordeaux Victor Segalen, Bordeaux, France. 4. Neurologist, Blaye, France. 5. Hôpital Suburbain du Bouscat, Le Bouscat, France. 6. Service de Neurologie, CHU Bordeaux, Pessac, France. 7. Service de neurologie, Clinique Saint Augustin, Bordeaux, France. 8. Service de neurologie, CH de Bayonne, Bayonne, France. 9. Neurologist, Bergerac, France. 10. Unité de Soins de Suite et Réadaptation gériatrique, CHU de Bordeaux, Bordeaux, France. 11. CMP des Fontaines de Monjous, Gradignan, France. 12. University Bordeaux Victor Segalen, Bordeaux, France Service de Neurologie, CHU Bordeaux, Pessac, France Université de Bordeaux-INSERM, Neurocentre Magendie, Bordeaux, France. 13. University Bordeaux Victor Segalen, Bordeaux, France Service de Gériatrie, CHU de Bordeaux, Pessac, France. 14. University Bordeaux Victor Segalen, Bordeaux, France Service de Neurologie, CHU Bordeaux, Pessac, France Université de Bordeaux, CNRS, Institut des Maladies Neurodégénératives, Bordeaux, France.
Abstract
BACKGROUND: Knowledge of functional evolution in dementia is crucial for the patients and their families as well as the clinician. OBJECTIVE: This review identifies scales and outcomes used to describe the natural history of functional decline and describes the natural history of functional decline in a representative clinical population sample of published studies of patients with Alzheimer's disease (AD). METHODS: A search of three relevant databases was conducted and limited to articles published in English and French between 1998 to March 2012, using the keywords "Dementia", "Activities of Daily Living", "Instrumental Activities of Daily Living", "Functional Impairment", "Prognosis", and "Disease Progression". RESULTS: The search strategy displayed 683 articles, 20 of which were found to be related to the functional evolution of AD. In these studies, different scales were used to describe the evolution of the functional decline, except for the decline of instrumental activities, for which the Lawton scale was used in all studies. Thus, it is difficult to represent the evolution of the functional decline from a clinical point of view. CONCLUSION: Relatively little data are available to estimate the functional evolution of AD. A consensus with broadened thought is required to know if the progression of the incapacities in these scales is additive or hierarchical.
BACKGROUND: Knowledge of functional evolution in dementia is crucial for the patients and their families as well as the clinician. OBJECTIVE: This review identifies scales and outcomes used to describe the natural history of functional decline and describes the natural history of functional decline in a representative clinical population sample of published studies of patients with Alzheimer's disease (AD). METHODS: A search of three relevant databases was conducted and limited to articles published in English and French between 1998 to March 2012, using the keywords "Dementia", "Activities of Daily Living", "Instrumental Activities of Daily Living", "Functional Impairment", "Prognosis", and "Disease Progression". RESULTS: The search strategy displayed 683 articles, 20 of which were found to be related to the functional evolution of AD. In these studies, different scales were used to describe the evolution of the functional decline, except for the decline of instrumental activities, for which the Lawton scale was used in all studies. Thus, it is difficult to represent the evolution of the functional decline from a clinical point of view. CONCLUSION: Relatively little data are available to estimate the functional evolution of AD. A consensus with broadened thought is required to know if the progression of the incapacities in these scales is additive or hierarchical.
Entities:
Keywords:
Activities of daily living; Alzheimer's disease; prognosis; review
Authors: Eric Jutkowitz; Richard F MacLehose; Joseph E Gaugler; Bryan Dowd; Karen M Kuntz; Robert L Kane Journal: J Gerontol A Biol Sci Med Sci Date: 2016-04-29 Impact factor: 6.053