| Literature DB >> 24326516 |
Wasim Khan1, Vincent Giampietro2, Cedric Ginestet3, Flavio Dell'Acqua1, David Bouls1, Steven Newhouse1, Richard Dobson1, Tobias Banaschewski4, Gareth J Barker2, Arun L W Bokde5, Christian Büchel6, Patricia Conrod7, Herta Flor4, Vincent Frouin8, Hugh Garavan9, Penny Gowland10, Anreas Heinz11, Bernd Ittermann12, Hervé Lemaître13, Frauke Nees4, Tomas Paus14, Zdenka Pausova15, Marcella Rietschel4, Michael N Smolka16, Andreas Ströhle11, Jean Gallinat11, Eric Westman17, Gunther Schumann3, Simon Lovestone1, Andrew Simmons1.
Abstract
Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these polymorphisms may only become apparent in later life.Entities:
Keywords: Apolipoprotein E; hippocampal volume; magnetic resonance imaging; young healthy adolescents
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Year: 2014 PMID： 24326516 DOI： 10.3233/JAD-131841
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472