Fernando Guerrero-Romero1, Luis E Simental-Mendía2, Martha Rodríguez-Morán1. 1. Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico, and General Hospital, Secretary of Health, Durango, Mexico. 2. Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico, and General Hospital, Secretary of Health, Durango, Mexico. Electronic address: luis_simental81@hotmail.com.
Abstract
BACKGROUND AND AIMS: Several studies show that high serum C-reactive protein (CRP) levels are associated with an increased risk of diabetes, data that strongly supports a possible role for inflammation in diabetogenesis. The aim of this study was to determine whether elevated CRP levels are associated with fasting plasma glucose (FPG) and/or postload glucose levels according to the glucose tolerance status. METHODS: A total of 169 healthy males and non-pregnant females aged 18-65 years were enrolled in a population-based cross-sectional study. Individuals were allocated into groups with a new diagnosis of normal glucose tolerance (NGT) (n = 82), impaired fasting glucose (IFG) (n = 54), and impaired glucose tolerance (IGT) (n = 33). Elevated CRP was defined by CRP levels >3.0 and <10.0 mg/L, IFG by FPG ≥100 and <126 mg/dL, and IGT by plasma glucose concentration 2 h postload ≥140 and <200 mg/dL. A multiple regression linear analysis adjusted by body mass index, waist circumference, and lipid profile was performed to evaluate the association between CRP levels (independent variable) with FPG and 2 h postload glucose levels (dependent variables). RESULTS: Multivariate linear regression analysis showed a significant association between hsCRP levels with FPG (β = 0.536; 95% CI 1.03-5.1, p = 0.005) and 2 h postload glucose (β = 0.209; 95% CI 1.31-2.97, p = 0.01) in the IGT group, but not with FPG (β = 0.147; 95% CI 0.55-2.0, p = 0.25) and 2 h postload glucose (β = 0.151; 95% CI 0.83-3.2, p = 0.24) in the IFG group. CONCLUSIONS: Elevated CRP levels are associated with FPG and 2 h postload glucose in the individuals with IGT, but not in subjects with IFG or NGT.
BACKGROUND AND AIMS: Several studies show that high serum C-reactive protein (CRP) levels are associated with an increased risk of diabetes, data that strongly supports a possible role for inflammation in diabetogenesis. The aim of this study was to determine whether elevated CRP levels are associated with fasting plasma glucose (FPG) and/or postload glucose levels according to the glucose tolerance status. METHODS: A total of 169 healthy males and non-pregnant females aged 18-65 years were enrolled in a population-based cross-sectional study. Individuals were allocated into groups with a new diagnosis of normal glucose tolerance (NGT) (n = 82), impaired fasting glucose (IFG) (n = 54), and impaired glucose tolerance (IGT) (n = 33). Elevated CRP was defined by CRP levels >3.0 and <10.0 mg/L, IFG by FPG ≥100 and <126 mg/dL, and IGT by plasma glucose concentration 2 h postload ≥140 and <200 mg/dL. A multiple regression linear analysis adjusted by body mass index, waist circumference, and lipid profile was performed to evaluate the association between CRP levels (independent variable) with FPG and 2 h postload glucose levels (dependent variables). RESULTS: Multivariate linear regression analysis showed a significant association between hsCRP levels with FPG (β = 0.536; 95% CI 1.03-5.1, p = 0.005) and 2 h postload glucose (β = 0.209; 95% CI 1.31-2.97, p = 0.01) in the IGT group, but not with FPG (β = 0.147; 95% CI 0.55-2.0, p = 0.25) and 2 h postload glucose (β = 0.151; 95% CI 0.83-3.2, p = 0.24) in the IFG group. CONCLUSIONS: Elevated CRP levels are associated with FPG and 2 h postload glucose in the individuals with IGT, but not in subjects with IFG or NGT.
Authors: Daniéla Oliveira Magro; Everton Cazzo; Paulo Gustavo Kotze; Ana Carolina Junqueira Vasques; Carlos Augusto Real Martinez; Elinton Adami Chaim; Bruno Geloneze; José Carlos Pareja; Cláudio Saddy Rodrigues Coy Journal: Obes Surg Date: 2018-02 Impact factor: 4.129
Authors: Ayaka Tsuboi; Kaori Kitaoka; Megumu Yano; Mika Takeuchi; Satomi Minato-Inokawa; Mari Honda; Miki Kurata; Bin Wu; Tsutomu Kazumi; Keisuke Fukuo Journal: BMJ Open Diabetes Res Care Date: 2020-10