Esra Guney1, Mehmet Fatih Ceylan2, Aysegul Tektas3, Murat Alisik4, Merve Ergin4, Zeynep Goker1, Gulser Senses Dinc1, Onder Ozturk1, Alperen Korkmaz5, Sevda Eker6, Murat Kizilgun7, Ozcan Erel4. 1. Ankara Pediatric & Pediatric Hematology Oncology Training and Research Hospital, Child and Adolescent Psychiatry Department, Ankara, Turkey. 2. Yildirim Beyazit University Faculty of Medicine, Child and Adolescent Psychiatry Department, Ankara, Turkey. Electronic address: mehmetfceylan@yahoo.com. 3. Eskisehir State Hospital, Department of Medical Biochemistry, Eskisehir, Turkey. 4. Yildirim Beyazit University Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey. 5. Yildirim Beyazit University Faculty of Medicine, Department of Psychiatry, Ankara, Turkey. 6. Ankara Pediatric & Pediatric Hematology Oncology Training and Research Hospital, Department of Pediatrics, Ankara, Turkey. 7. Ankara Pediatric & Pediatric Hematology Oncology Training and Research Hospital, Department of Medical Biochemistry, Ankara, Turkey.
Abstract
BACKGROUND: Anxiety disorders are common in children and adolescents, and they can significantly impair quality of life. Genetic, neurobiological, neurochemical, and psychological factors are believed to play a role in the etiopathogenesis of anxiety disorders. Recent evidence suggests that the pathophysiology of anxiety disorders may be associated with oxidative stress. In this study, we investigated whether there are associations between children with anxiety disorders and total oxidant/antioxidant status. METHODS: The experimental group consisted of 40 patients (children and adolescents) with anxiety disorders. An age- and gender-matched control group composed of 35 healthy subjects was also assessed. Venous blood samples were collected and total antioxidative status (TAS), total oxidative status (TOS), and the oxidative stress index (OSI) were determined. RESULTS: Both the TOS and the OSI of the experimental group were significantly higher than those of the control group. There were no significant differences in TAS between the experimental and control groups. LIMITATIONS: The main limitation of our study was the small sample size. CONCLUSIONS: This study suggests that oxidative balance is impaired in children with anxiety disorders. Oxidative stress may play a role in the etiopathogenesis of anxiety disorders, and TOS may be a useful diagnostic tool in this context.
BACKGROUND:Anxiety disorders are common in children and adolescents, and they can significantly impair quality of life. Genetic, neurobiological, neurochemical, and psychological factors are believed to play a role in the etiopathogenesis of anxiety disorders. Recent evidence suggests that the pathophysiology of anxiety disorders may be associated with oxidative stress. In this study, we investigated whether there are associations between children with anxiety disorders and total oxidant/antioxidant status. METHODS: The experimental group consisted of 40 patients (children and adolescents) with anxiety disorders. An age- and gender-matched control group composed of 35 healthy subjects was also assessed. Venous blood samples were collected and total antioxidative status (TAS), total oxidative status (TOS), and the oxidative stress index (OSI) were determined. RESULTS: Both the TOS and the OSI of the experimental group were significantly higher than those of the control group. There were no significant differences in TAS between the experimental and control groups. LIMITATIONS: The main limitation of our study was the small sample size. CONCLUSIONS: This study suggests that oxidative balance is impaired in children with anxiety disorders. Oxidative stress may play a role in the etiopathogenesis of anxiety disorders, and TOS may be a useful diagnostic tool in this context.
Authors: Eunkyoung Kim; Yi Liu; Hadar Ben-Yoav; Thomas E Winkler; Kun Yan; Xiaowen Shi; Jana Shen; Deanna L Kelly; Reza Ghodssi; William E Bentley; Gregory F Payne Journal: Adv Healthc Mater Date: 2016-09-12 Impact factor: 9.933