Literature DB >> 24325280

Stereodivergent synthesis of enantioenriched 4-hydroxy-2-cyclopentenones.

Gurpreet Singh1, Angelica Meyer, Jeffrey Aubé.   

Abstract

Protected 4-hydroxycyclopentenones (4-HCPs) constitute an important class of intermediates in chemical synthesis. A route to this class of compound has been developed. Key steps include Noyori reduction (which establishes the stereochemistry of the product), ring-closing metathesis, and simple functional group conversions to provide a set of substituted 4-HCPs in either enantiomeric form.

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Year:  2013        PMID： 24325280      PMCID： PMC3941174          DOI： 10.1021/jo402539p

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  15 in total

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9.  The thio-adduct facilitated, enzymatic kinetic resolution of 4-hydroxycyclopentenone and 4-hydroxycyclohexenone.

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2.  Catalysis-Enabled Concise and Stereoselective Total Synthesis of the Tricyclic Prostaglandin D2 Metabolite Methyl Ester.

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  2 in total

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