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Literature DB >> 24323648

Intracranial delivery of stem cells.

Keith W Muir¹, John Sinden, Erik Miljan, Laurence Dunn.

Abstract

The method of delivery of stem cells is a major factor to consider in the design of clinical trials of cell therapy. Different methods of delivery will be associated with different risks to the patient, and may also be associated with different potential for benefit. Current approaches are partly informed by the routes selected for study in animal models of focal ischaemia and CNS transplantation, but there has been little work comparing the efficacy of different routes of administration. Direct intraparenchymal delivery of cells has been employed in several preliminary clinical trials, and data on the safety of this approach are reviewed.

Entities: Disease Species

Year: 2011 PMID： 24323648 DOI： 10.1007/s12975-011-0095-z

Source DB: PubMed Journal: Transl Stroke Res ISSN： 1868-4483 Impact factor: 6.829

45 in total

1. Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475.

Authors: A E Rosser; R A Barker; T Harrower; C Watts; M Farrington; A K Ho; R M Burnstein; D K Menon; J H Gillard; J Pickard; S B Dunnett
Journal: J Neurol Neurosurg Psychiatry Date: 2002-12 Impact factor: 10.154

2. Technical factors that influence neural transplant safety in Huntington's disease.

Authors: T B Freeman; F Cicchetti; A C Bachoud-Lévi; S B Dunnett
Journal: Exp Neurol Date: 2010-09-16 Impact factor: 5.330

3. Bilateral human fetal striatal transplantation in Huntington's disease.

Authors: R A Hauser; S Furtado; C R Cimino; H Delgado; S Eichler; S Schwartz; D Scott; G M Nauert; E Soety; V Sossi; D A Holt; P R Sanberg; A J Stoessl; T B Freeman
Journal: Neurology Date: 2002-03-12 Impact factor: 9.910

4. Risk factors for hemorrhage during microelectrode-guided deep brain stimulator implantation for movement disorders.

Authors: Devin K Binder; Geoff M Rau; Philip A Starr
Journal: Neurosurgery Date: 2005-04 Impact factor: 4.654

5. Outcomes and complications of fetal tissue transplantation in Parkinson's disease.

Authors: D B Jacques; O V Kopyov; K S Eagle; T Carter; A Lieberman
Journal: Stereotact Funct Neurosurg Date: 1999 Impact factor: 1.875

6. Treatment of stroke in rat with intracarotid administration of marrow stromal cells.

Authors: Y Li; J Chen; L Wang; M Lu; M Chopp
Journal: Neurology Date: 2001-06-26 Impact factor: 9.910

7. Transplantation of embryonic porcine mesencephalic tissue in patients with PD.

Authors: J M Schumacher; S A Ellias; E P Palmer; H S Kott; J Dinsmore; P K Dempsey; A J Fischman; C Thomas; R G Feldman; S Kassissieh; R Raineri; C Manhart; D Penney; J S Fink; O Isacson
Journal: Neurology Date: 2000-03-14 Impact factor: 9.910

8. Implantation of human fetal ventral mesencephalon to the right caudate nucleus in advanced Parkinson's disease.

Authors: B T Henderson; C G Clough; R C Hughes; E R Hitchcock; B G Kenny
Journal: Arch Neurol Date: 1991-08

9. Incidence of symptomatic hemorrhage after stereotactic electrode placement.

Authors: Charles A Sansur; Robert C Frysinger; Nader Pouratian; Kai-Ming Fu; Markus Bittl; Rod J Oskouian; Edward R Laws; W Jeffrey Elias
Journal: J Neurosurg Date: 2007-11 Impact factor: 5.115

10. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease.

Authors: C Warren Olanow; Christopher G Goetz; Jeffrey H Kordower; A Jon Stoessl; Vesna Sossi; Mitchell F Brin; Kathleen M Shannon; G Michael Nauert; Daniel P Perl; James Godbold; Thomas B Freeman
Journal: Ann Neurol Date: 2003-09 Impact factor: 10.422

7 in total

Intracranial delivery of stem cells.

1. Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475.

2. Technical factors that influence neural transplant safety in Huntington's disease.

3. Bilateral human fetal striatal transplantation in Huntington's disease.

4. Risk factors for hemorrhage during microelectrode-guided deep brain stimulator implantation for movement disorders.

5. Outcomes and complications of fetal tissue transplantation in Parkinson's disease.

6. Treatment of stroke in rat with intracarotid administration of marrow stromal cells.

7. Transplantation of embryonic porcine mesencephalic tissue in patients with PD.

8. Implantation of human fetal ventral mesencephalon to the right caudate nucleus in advanced Parkinson's disease.

9. Incidence of symptomatic hemorrhage after stereotactic electrode placement.

10. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease.

Review 1. Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound.

Review 2. Stem Cell Therapies for Progressive Multiple Sclerosis.

Review 3. Human Neural Stem Cell Therapy for Chronic Ischemic Stroke: Charting Progress from Laboratory to Patients.

Review 4. Clinical imaging in regenerative medicine.

Review 5. Emerging Imaging Modalities in Regenerative Medicine.

Review 6. Regeneration after stroke: Stem cell transplantation and trophic factors.

Review 7. Enhancing Brain Plasticity to Promote Stroke Recovery.