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Literature DB >> 24322348

The effects of elastic fiber protein insufficiency and treatment on the modulus of arterial smooth muscle cells.

M Gabriela Espinosa, William S Gardner, Lisa Bennett, Bradley A Sather, Hiromi Yanagisawa, Jessica E Wagenseil.

Abstract

Elastic fibers are critical for the mechanical function of the large arteries. Mechanical effects of elastic fiber protein deficiency have been investigated in whole arteries, but not in isolated smooth muscle cells (SMCs). The elastic moduli of SMCs from elastin (Eln-/-) and fibulin-4 (Fbln4-/-) knockout mice were measured using atomic force microscopy. Compared to control SMCs, the modulus of Eln-/- SMCs is reduced by 40%, but is unchanged in Fbln4-/- SMCs. The Eln-/- SMC modulus is rescued by soluble or α elastin treatment. Altered gene expression, specifically of calponin, suggests that SMC phenotypic modulation may be responsible for the modulus changes.

Entities: Disease Gene Species

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Year: 2014 PMID： 24322348 PMCID： PMC5101025 DOI： 10.1115/1.4026203

Source DB: PubMed Journal: J Biomech Eng ISSN： 0148-0731 Impact factor: 2.097

31 in total

1. Smooth muscle specific expression of calponin.

Authors: M Gimona; M Herzog; J Vandekerckhove; J V Small
Journal: FEBS Lett Date: 1990-11-12 Impact factor: 4.124

Review 2. Mechanical, biochemical, and extracellular matrix effects on vascular smooth muscle cell phenotype.

Authors: Jan P Stegemann; Helen Hong; Robert M Nerem
Journal: J Appl Physiol (1985) Date: 2005-06

3. Calponin and mitogen-activated protein kinase signaling in differentiated vascular smooth muscle.

Authors: C B Menice; J Hulvershorn; L P Adam; C A Wang; K G Morgan
Journal: J Biol Chem Date: 1997-10-03 Impact factor: 5.157

Review 4. Atomic force microscopy in mechanobiology: measuring microelastic heterogeneity of living cells.

Authors: Evren U Azeloglu; Kevin D Costa
Journal: Methods Mol Biol Date: 2011

5. A lamellar unit of aortic medial structure and function in mammals.

Authors: H Wolinsky; S Glagov
Journal: Circ Res Date: 1967-01 Impact factor: 17.367

Review 6. Phenotype modulation of airway smooth muscle in asthma.

Authors: David B Wright; Thomas Trian; Sana Siddiqui; Chris D Pascoe; Jill R Johnson; Bart G J Dekkers; Shyamala Dakshinamurti; Rushita Bagchi; Janette K Burgess; Varsha Kanabar; Oluwaseun O Ojo
Journal: Pulm Pharmacol Ther Date: 2012-08-23 Impact factor: 3.410

7. Short communication: vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging.

Authors: Hongyu Qiu; Yi Zhu; Zhe Sun; Jerome P Trzeciakowski; Meredith Gansner; Christophe Depre; Ranillo R G Resuello; Filipinas F Natividad; William C Hunter; Guy M Genin; Elliot L Elson; Dorothy E Vatner; Gerald A Meininger; Stephen F Vatner
Journal: Circ Res Date: 2010-07-15 Impact factor: 17.367

6. Captopril treatment during development alleviates mechanically induced aortic remodeling in newborn elastin knockout mice.

Authors: Jungsil Kim; Austin J Cocciolone; Marius C Staiculescu; Robert P Mecham; Jessica E Wagenseil
Journal: Biomech Model Mechanobiol Date: 2019-07-03

6 in total

The effects of elastic fiber protein insufficiency and treatment on the modulus of arterial smooth muscle cells.

1. Smooth muscle specific expression of calponin.

Review 2. Mechanical, biochemical, and extracellular matrix effects on vascular smooth muscle cell phenotype.

3. Calponin and mitogen-activated protein kinase signaling in differentiated vascular smooth muscle.

Review 4. Atomic force microscopy in mechanobiology: measuring microelastic heterogeneity of living cells.

5. A lamellar unit of aortic medial structure and function in mammals.

Review 6. Phenotype modulation of airway smooth muscle in asthma.

7. Short communication: vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging.

8. Reduced vessel elasticity alters cardiovascular structure and function in newborn mice.

Review 9. New insights into elastic fiber assembly.

10. Novel arterial pathology in mice and humans hemizygous for elastin.

Review 1. Elastic Fibers and Large Artery Mechanics in Animal Models of Development and Disease.

Review 2. Elastin, arterial mechanics, and stenosis.

3. Reduced embryonic blood flow impacts extracellular matrix deposition in the maturing aorta.

Review 4. Elastin, arterial mechanics, and cardiovascular disease.

Review 5. Engineering Smooth Muscle to Understand Extracellular Matrix Remodeling and Vascular Disease.

6. Captopril treatment during development alleviates mechanically induced aortic remodeling in newborn elastin knockout mice.