Haejin Kim1, Christine C Johnson. 1. aDivision of Allergy and Clinical Immunology bDepartment of Public Health Sciences, Henry Ford Health System, Detroit, Michigan, USA.
Abstract
PURPOSE OF REVIEW: To examine the literature evidence for the association between acetaminophen (paracetamol) use and development of rhinitis. RECENT FINDINGS: Increased use of acetaminophen (paracetamol) as the favored antipyretic during pregnancy and infancy has been hypothesized to be a risk factor for the development of asthma. There is a paucity of well designed birth cohort studies to examine paracetamol as a risk factor in the development of rhinitis. Confounding by antibiotic use, viral infections, and recall bias are problematic for many of the studies that are published. SUMMARY: Prospective birth cohorts need to dedicate sufficient time and research personnel to adequately assess paracetamol exposure as a primary variable of interest rather than as an incidental exposure variable collected during routine questionnaire administration.
PURPOSE OF REVIEW: To examine the literature evidence for the association between acetaminophen (paracetamol) use and development of rhinitis. RECENT FINDINGS: Increased use of acetaminophen (paracetamol) as the favored antipyretic during pregnancy and infancy has been hypothesized to be a risk factor for the development of asthma. There is a paucity of well designed birth cohort studies to examine paracetamol as a risk factor in the development of rhinitis. Confounding by antibiotic use, viral infections, and recall bias are problematic for many of the studies that are published. SUMMARY: Prospective birth cohorts need to dedicate sufficient time and research personnel to adequately assess paracetamol exposure as a primary variable of interest rather than as an incidental exposure variable collected during routine questionnaire administration.
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