Literature DB >> 24321407

BDNF in quinolinic acid lesioned rats after bone marrow cells transplant.

T Serrano Sánchez1, E Alberti Amador1, L Lorigados Pedre1, L Blanco Lezcano1, I Diaz Armesto1, J A Bergado2.   

Abstract

Brain-derived neurotrophic factor (BDNF) concentration was measured in the striatum and cortex after quinolinic acid intrastriatal lesion and transplantation of bone marrow cells (BMSC). The results showed a significant increase of the BDNF levels in the striatum and cortex of the lesioned animals and the ability of the transplanted cells to increase the levels of BDNF in both sites. This recovery of BDNF production and distribution might have beneficial effects and ameliorate the negative consequences of the striatal lesion, a mechanism of potential interest for the treatment of Huntington's disease (HD).
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Bone marrow stem cells (BMC); Brain-derived neurotrophic factor (BDNF); Huntington's disease (HD); Quinolinic acid; Transplant

Mesh：

Substances：

Year:  2013        PMID： 24321407     DOI： 10.1016/j.neulet.2013.11.060

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


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4.  Rotating and Neurochemical Activity of Rats Lesioned with Quinolinic Acid and Transplanted with Bone Marrow Mononuclear Cells.

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