| Literature DB >> 24320209 |
Fei Yang1, Haiming Shi, Xiaowei Zhang, Liangli Lucy Yu.
Abstract
Two novel 20-oxo-21-nordammar-22, 24-diene saponins, 21-norgypenosides A (1) and B (2), were characterized from the aerial parts of tetraploid Jiaogulan ( Gynostemma pentaphyllum ), a popular tea ingredient. Their structures, including the absolute configurations, were comprehensively elucidated by HRESIMS, 1D and 2D NMR data, chemical degradation, and through comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. The two compounds suppressed the expression of interleukin (IL)-1β, cyclooxygenase (COX)-2, and tumor necrosis factor (TNF)-α mRNAs in the lipopolysaccharide-induced RAW 264.7 mouse macrophage cells at 10 and 100 μg/mL, suggesting their potential anti-inflammatory effects.Entities:
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Year: 2013 PMID： 24320209 DOI： 10.1021/jf404726z
Source DB: PubMed Journal: J Agric Food Chem ISSN： 0021-8561 Impact factor: 5.279