BACKGROUND: Actinic cheilitis (AC) is a potentially malignant disorder of the lip caused by exposure to solar radiation. OBJECTIVES: This study was conducted to evaluate the clinicopathologic profile of cases of AC and to verify associations with the degree of dysplasia. METHODS: This retrospective study analyzed data for 40 patients with AC. Demographic, clinical, and histopathologic data were evaluated. Sections measuring 5 μm in thickness were cut, deparaffinized, and stained with hematoxylin and eosin for histologic examination. The degree of epithelial dysplasia was graded using the criteria defined by the World Health Organization. Two calibrated oral pathologists analyzed the slides. RESULTS: Analysis of the AC patients sampled showed that 75.0% were male (P=0.002), 80.0% were aged≥40 years (P<0.001), 74.3% were Caucasian (P=0.004), and 68.6% had occupational exposure to sunlight (P=0.028). The most common clinical manifestation was white lesions (55.0%), and 40.0% of patients had no dysplasia. No significant associations emerged between the histologic grading of AC and gender (P=1.000), age (P=1.000), ethnicity (P=0.416), occupational exposure to sunlight (P=1.000), and clinical presentation (P=0.467). CONCLUSIONS: The degree of dysplasia in AC was not statistically associated with gender, age, ethnicity, occupational exposure to sunlight, or clinical appearance. This study provides some support for the hypothesis that clinicopathologic features are not related to the degree of dysplasia in AC.
BACKGROUND:Actinic cheilitis (AC) is a potentially malignant disorder of the lip caused by exposure to solar radiation. OBJECTIVES: This study was conducted to evaluate the clinicopathologic profile of cases of AC and to verify associations with the degree of dysplasia. METHODS: This retrospective study analyzed data for 40 patients with AC. Demographic, clinical, and histopathologic data were evaluated. Sections measuring 5 μm in thickness were cut, deparaffinized, and stained with hematoxylin and eosin for histologic examination. The degree of epithelial dysplasia was graded using the criteria defined by the World Health Organization. Two calibrated oral pathologists analyzed the slides. RESULTS: Analysis of the AC patients sampled showed that 75.0% were male (P=0.002), 80.0% were aged≥40 years (P<0.001), 74.3% were Caucasian (P=0.004), and 68.6% had occupational exposure to sunlight (P=0.028). The most common clinical manifestation was white lesions (55.0%), and 40.0% of patients had no dysplasia. No significant associations emerged between the histologic grading of AC and gender (P=1.000), age (P=1.000), ethnicity (P=0.416), occupational exposure to sunlight (P=1.000), and clinical presentation (P=0.467). CONCLUSIONS: The degree of dysplasia in AC was not statistically associated with gender, age, ethnicity, occupational exposure to sunlight, or clinical appearance. This study provides some support for the hypothesis that clinicopathologic features are not related to the degree of dysplasia in AC.
Authors: Leni Verônica de Oliveira Silva; José Alcides Almeida de Arruda; Lucas Guimarães Abreu; Raquel Conceição Ferreira; Leorik Pereira da Silva; Cibele Pelissari; Ricardo Natã Fonseca Silva; Kaio Heide Sampaio Nóbrega; Bruno Augusto Benevenuto de Andrade; Mario José Romañach; Michelle Agostini; Cassiano Francisco Weege Nonaka; Pollianna Muniz Alves; Hélder Antônio Rebelo Pontes; Luís Fernando Rivero; Lélia Batista de Souza; Marília Trierveiler; Elismauro Francisco Mendonça; Ana Paula Neutzling Gomes; Manoela Domingues Martins; Emanuel Sávio de Souza Andrade; Marcia Maria Fonseca da Silveira; Ana Paula Veras Sobral; Ricardo Alves Mesquita Journal: Head Neck Pathol Date: 2020-02-19
Authors: Hanna Isa de Oliveira Bezerra; Amanda Katarinny Goes Gonzaga; Éricka Janine Dantas da Silveira; Patrícia Teixeira de Oliveira; Ana Miryam Costa de Medeiros Journal: Clin Oral Investig Date: 2019-01-23 Impact factor: 3.573
Authors: Maria Luiza Diniz de Sousa Lopes; Francisco Leonardo da Silva Júnior; Kenio Costa Lima; Patrícia Teixeira de Oliveira; Éricka Janine Dantas da Silveira Journal: An Bras Dermatol Date: 2015 Jul-Aug Impact factor: 1.896