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Literature DB >> 2431998

A monoclonal antibody recognizing the p150/95 leucocyte differentiation antigen.

S M MacDonald, K Pulford, B Falini, K Micklem, D Y Mason.

Abstract

A monoclonal antibody KB90 recognizing a molecule containing two polypeptide subunits of 140 and 98 kd is described. Biochemical studies following high pH dissociation of the molecule showed KB90 to bind to an epitope on the 140 kd subunit. The molecule recognized by KB90 appears to correspond to the p150/95 molecule in the family of leucocyte differentiation antigens of which the LFA-1 and Mac-1 molecules are members. Analysis of the immunocytochemical reactivity of KB90 shows that it stains monocytes, tissue macrophages, granulocytes and a small population of lymphocytes. These reactions are clearly distinct from those of the LFA-1 and Mac-1 molecules.

Entities: Gene

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Year: 1986 PMID： 2431998 PMCID： PMC1453183

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

20 in total

1. LFA-1, LFA-2, and LFA-3 antigens are involved in CTL-target conjugation.

Authors: A M Krensky; E Robbins; T A Springer; S J Burakoff
Journal: J Immunol Date: 1984-05 Impact factor: 5.422

2. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

Authors: J L Cordell; B Falini; W N Erber; A K Ghosh; Z Abdulaziz; S MacDonald; K A Pulford; H Stein; D Y Mason
Journal: J Histochem Cytochem Date: 1984-02 Impact factor: 2.479

3. Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies.

Authors: S D Wright; P E Rao; W C Van Voorhis; L S Craigmyle; K Iida; M A Talle; E F Westberg; G Goldstein; S C Silverstein
Journal: Proc Natl Acad Sci U S A Date: 1983-09 Impact factor: 11.205

4. The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions.

Authors: A M Krensky; F Sanchez-Madrid; E Robbins; J A Nagy; T A Springer; S J Burakoff
Journal: J Immunol Date: 1983-08 Impact factor: 5.422

5. A monoclonal antibody reactive with human peripheral blood monocytes.

Authors: J Breard; E L Reinherz; P C Kung; G Goldstein; S F Schlossman
Journal: J Immunol Date: 1980-04 Impact factor: 5.422

6. A human lymphocyte-associated antigen involved in cell-mediated lympholysis.

Authors: J E Hildreth; F M Gotch; P D Hildreth; A J McMichael
Journal: Eur J Immunol Date: 1983-03 Impact factor: 5.532

7. Antigens on human monocytes identified by monoclonal antibodies.

Authors: R F Todd; L M Nadler; S F Schlossman
Journal: J Immunol Date: 1981-04 Impact factor: 5.422

8. Immunocytochemical detection of T and B cell populations in routine blood smears.

Authors: W N Erber; A J Pinching; D Y Mason
Journal: Lancet Date: 1984-05-12 Impact factor: 79.321

9. Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor.

Authors: D I Beller; T A Springer; R D Schreiber
Journal: J Exp Med Date: 1982-10-01 Impact factor: 14.307

10. A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

Authors: F Sanchez-Madrid; J A Nagy; E Robbins; P Simon; T A Springer
Journal: J Exp Med Date: 1983-12-01 Impact factor: 14.307

7 in total

7. The origin and nature of stromal osteoclast-like multinucleated giant cells in breast carcinoma: implications for tumour osteolysis and macrophage biology.

Authors: N A Athanasou; C A Wells; J Quinn; D P Ferguson; A Heryet; J O McGee
Journal: Br J Cancer Date: 1989-04 Impact factor: 7.640

7 in total

A monoclonal antibody recognizing the p150/95 leucocyte differentiation antigen.

1. LFA-1, LFA-2, and LFA-3 antigens are involved in CTL-target conjugation.

2. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

3. Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies.

4. The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions.

5. A monoclonal antibody reactive with human peripheral blood monocytes.

6. A human lymphocyte-associated antigen involved in cell-mediated lympholysis.

7. Antigens on human monocytes identified by monoclonal antibodies.

8. Immunocytochemical detection of T and B cell populations in routine blood smears.

9. Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor.

10. A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

1. Ber-MAC3: new monoclonal antibody that defines human monocyte/macrophage differentiation antigen.

2. Differential MHC class II expression on human peripheral blood monocytes and dendritic cells.

3. Diagnostic application of monoclonal antibody KB90 (CD11c) in acute myeloid leukaemia.

4. Monoclonal antibody (Y1/82A) with specificity towards peripheral blood monocytes and tissue macrophages.

5. EBM/11 reactivity in malignant histiocytosis.

6. Surface markers of axolotl lymphocytes as defined by monoclonal antibodies.

7. The origin and nature of stromal osteoclast-like multinucleated giant cells in breast carcinoma: implications for tumour osteolysis and macrophage biology.