Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Roles of Mitochondrial DNA Changes on Cancer Initiation and Progression.

Literature DB >> 24319697

Roles of Mitochondrial DNA Changes on Cancer Initiation and Progression.

Masahiro Higuchi¹.

Abstract

Entities: CellLine Chemical Disease Gene Species

Year: 2012 PMID： 24319697 PMCID： PMC3851107 DOI： 10.4172/2324-9293.1000e109

Source DB: PubMed Journal: Cell Biol (Henderson, NV) ISSN： 2324-9293

× No keyword cloud information.

40 in total

1. Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions.

Authors: G Van Goethem; B Dermaut; A Löfgren; J J Martin; C Van Broeckhoven
Journal: Nat Genet Date: 2001-07 Impact factor: 38.330

2. Constitutive activation of AKT pathway inhibits TNF-induced apoptosis in mitochondrial DNA-deficient human myelogenous leukemia ML-1a.

Authors: Seigo Suzuki; Akihiro Naito; Takayuki Asano; Teresa T Evans; Shrikanth A G Reddy; Masahiro Higuchi
Journal: Cancer Lett Date: 2008-05-12 Impact factor: 8.679

3. Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells.

Authors: Haihong Zhang; Takatsugu Mizumachi; Jaime Carcel-Trullols; Liwen Li; Akihiro Naito; Horace J Spencer; Paul M Spring; Bruce R Smoller; Amanda J Watson; Geoffrey P Margison; Masahiro Higuchi; Chun-Yang Fan
Journal: Carcinogenesis Date: 2007-03-26 Impact factor: 4.944

4. Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage.

Authors: Hiroko P Indo; Mercy Davidson; Hsiu-Chuan Yen; Shigeaki Suenaga; Kazuo Tomita; Takeshi Nishii; Masahiro Higuchi; Yasutoshi Koga; Toshihiko Ozawa; Hideyuki J Majima
Journal: Mitochondrion Date: 2006-12-13 Impact factor: 4.160

5. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.

Authors: Kaori Ishikawa; Keizo Takenaga; Miho Akimoto; Nobuko Koshikawa; Aya Yamaguchi; Hirotake Imanishi; Kazuto Nakada; Yoshio Honma; Jun-Ichi Hayashi
Journal: Science Date: 2008-04-03 Impact factor: 47.728

6. Heteroplasmic mutation of mitochondrial DNA D-loop and 4977-bp deletion in human cancer cells during mitochondrial DNA depletion.

Authors: Hsin-Chen Lee; Li-Sung Hsu; Pen-Hui Yin; Liang-Ming Lee; Chin-Wen Chi
Journal: Mitochondrion Date: 2006-12-08 Impact factor: 4.160

Roles of Mitochondrial DNA Changes on Cancer Initiation and Progression.

1. Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions.

2. Constitutive activation of AKT pathway inhibits TNF-induced apoptosis in mitochondrial DNA-deficient human myelogenous leukemia ML-1a.

3. Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells.

4. Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage.

5. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.

6. Heteroplasmic mutation of mitochondrial DNA D-loop and 4977-bp deletion in human cancer cells during mitochondrial DNA depletion.

7. Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae.

Review 8. Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis.

9. Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells.

10. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria.

1. Expression of mitochondrial genes MT-ND1, MT-ND6, MT-CYB, MT-COI, MT-ATP6, and 12S/MT-RNR1 in colorectal adenopolyps.

2. Mitochondrial DNA copy number in peripheral blood leukocytes and the aggressiveness of localized prostate cancer.