Literature DB >> 2431915

Endothelium-dependent relaxation of human epicardial coronary arteries: frequent lack of effect of acetylcholine.

U Förstermann, A Mügge, J C Frölich.   

Abstract

Strip preparations of human epicardial coronary arteries (free of atherosclerosis) relaxed in an endothelium-dependent fashion to substance P and Ca2+-ionophore A23187. Acetylcholine generally caused contraction in the same strips. Glyceryl trinitrate and isoproterenol induced relaxation irrespective of the presence or absence of endothelium. Nordihydroguaiaretic acid abolished the relaxation produced by substance P and A23187. Mepacrine only blocked substance P relaxation. Haemoglobin and methylene blue inhibited substance P and A23187 relaxations but also reduced the response to glyceryl trinitrate. These inhibitor experiments indicate that human coronary arteries are relaxed by the endothelium-derived relaxing factor.

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Year:  1986        PMID： 2431915     DOI： 10.1016/0014-2999(86)90778-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  10 in total

1.  Binding of muscarine receptor antagonists to pig coronary smooth muscle.

Authors:  I Rinner; H N Doods; K J van Charldorp; D Davidesko; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-02       Impact factor: 3.000

2.  The influence of atherosclerosis on the mechanical responses of human isolated coronary arteries to substance P, isoprenaline and noradrenaline.

Authors:  G Berkenboom; M Depierreux; J Fontaine
Journal:  Br J Pharmacol       Date:  1987-09       Impact factor: 8.739

3.  Daily pattern of skin microcirculation in conscious laboratory rats.

Authors:  R F Hertel
Journal:  Naturwissenschaften       Date:  1987-12

4.  Calcitonin gene-related peptide and human epicardial coronary arteries: presence, release and vasodilator effects.

Authors:  A Franco-Cereceda
Journal:  Br J Pharmacol       Date:  1991-02       Impact factor: 8.739

Review 5.  Inducible endothelium-derived hyperpolarizing factor: role of the 15-lipoxygenase-EDHF pathway.

Authors:  William B Campbell; Kathryn M Gauthier
Journal:  J Cardiovasc Pharmacol       Date:  2013-03       Impact factor: 3.105

6.  Atherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise.

Authors:  J B Gordon; P Ganz; E G Nabel; R D Fish; J Zebede; G H Mudge; R W Alexander; A P Selwyn
Journal:  J Clin Invest       Date:  1989-06       Impact factor: 14.808

7.  Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries.

Authors:  M Nakashima; J V Mombouli; A A Taylor; P M Vanhoutte
Journal:  J Clin Invest       Date:  1993-12       Impact factor: 14.808

8.  Modulatory role of the vascular endothelium in the contractility of human isolated internal mammary artery.

Authors:  P Schoeffter; R Dion; T Godfraind
Journal:  Br J Pharmacol       Date:  1988-10       Impact factor: 8.739

9.  Pharmacological reactivity of human epicardial coronary arteries: characterization of relaxation responses to endothelium-derived relaxing factor.

Authors:  A P Stork; T M Cocks
Journal:  Br J Pharmacol       Date:  1994-12       Impact factor: 8.739

Review 10.  Role of arachidonic acid lipoxygenase metabolites in the regulation of vascular tone.

Authors:  Yuttana Chawengsub; Kathryn M Gauthier; William B Campbell
Journal:  Am J Physiol Heart Circ Physiol       Date:  2009-06-12       Impact factor: 4.733
  10 in total

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