Cocaine effects on electroencephalographic cognitive event-related potentials and performance.

The effects of cocaine on electroencephalographic indices, information processing and motor performance were measured in 12 normal volunteers. They were tested with an auditory continuous performance task before, 60 and 180 min after a 3 mg/kg oral dose of cocaine hydrochloride or placebo in a double-blind counterbalanced crossover design. EEG from Fz, Cz and Pz were averaged for the eye movement-free correct trials. N100, P200, P300 components and CNV were measured. Cocaine increased N100 amplitude for the warning stimulus and CNV amplitude. P300 amplitude and latency, reaction time and sensory sensitivity (d') were not altered by cocaine. The increase in N100 and CNV amplitude may reflect mobilization of additional attentional resources to produce optimal performance on the task when subjects were distracted by the cardiovascular, subjective and other cocaine effects.

RCT Entities:   Population Interventions Outcomes