Literature DB >> 24318407

Epigenetics and ocular diseases: from basic biology to clinical study.

Biao Yan1, Jin Yao, Zhi-Fu Tao, Qin Jiang.   

Abstract

Epigenetics is an emerging field in ophthalmology and has opened a new avenue for understanding ocular development and ocular diseases related to aging and environment. Epigenetic mechanisms, including DNA methylation, histone modifications, chromatin remodeling, and deployment of non-coding RNAs, result in the heritable silencing of gene expression without any change in DNA sequence. Accumulating evidence suggests a potential link between gene expression, chromatin structure, non-coding RNAs, and cellular differentiation during ocular development. Disruption of the balance of epigenetic networks could become the etiology of several ocular diseases. Here, we summarized the current knowledge about epigenetic regulatory mechanisms in ocular development and diseases.
© 2013 Wiley Periodicals, Inc.

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Year:  2014        PMID： 24318407     DOI： 10.1002/jcp.24522

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  9 in total

1.  Unfolded protein response is activated in aged retinas.

Authors:  Austin R Lenox; Yogesh Bhootada; Oleg Gorbatyuk; Roderick Fullard; Marina Gorbatyuk
Journal:  Neurosci Lett       Date:  2015-10-17       Impact factor: 3.046

Review 2.  Epigenetic regulation of anterior segment diseases and potential therapeutics.

Authors:  Eric Chen; Kelley Bohm; Mark Rosenblatt; Kai Kang
Journal:  Ocul Surf       Date:  2020-04-25       Impact factor: 5.033

Review 3.  Epigenetics and Common Ophthalmic Diseases.

Authors:  Wendy Li; Ji Liu; Jennifer A Galvin
Journal:  Yale J Biol Med       Date:  2016-12-23

4.  DNA Methylomes Reveal Biological Networks Involved in Human Eye Development, Functions and Associated Disorders.

Authors:  María Berdasco; Antonio Gómez; Marcos J Rubio; Jaume Català-Mora; Vicente Zanón-Moreno; Miguel Lopez; Cristina Hernández; Shigeo Yoshida; Takahito Nakama; Keijiro Ishikawa; Tatsuro Ishibashi; Amina M Boubekeur; Lotfi Louhibi; Miguel A Pujana; Sergi Sayols; Fernando Setien; Dolores Corella; Carmen de Torres; Andreu Parareda; Jaume Mora; Ling Zhao; Kang Zhang; Matilde E Lleonart; Javier Alonso; Rafael Simó; Josep M Caminal; Manel Esteller
Journal:  Sci Rep       Date:  2017-09-18       Impact factor: 4.379

5.  Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study.

Authors:  Ellen Nordal; Veronika Rypdal; Terje Christoffersen; Kristiina Aalto; Lillemor Berntson; Anders Fasth; Troels Herlin; Susan Nielsen; Suvi Peltoniemi; Bjørn Straume; Marek Zak; Marite Rygg
Journal:  Pediatr Rheumatol Online J       Date:  2017-08-18       Impact factor: 3.054

6.  Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy.

Authors:  Emily Khuc; Russell Bainer; Marie Wolf; Selene M Clay; Daniel J Weisenberger; Jacquelyn Kemmer; Valerie M Weaver; David G Hwang; Matilda F Chan
Journal:  PLoS One       Date:  2017-04-06       Impact factor: 3.240

Review 7.  Applications of Non-Coding RNAs in Patients With Retinoblastoma.

Authors:  Daniel Fernandez-Diaz; Cristina Rodriguez-Vidal; Paula Silva-Rodríguez; Laura Paniagua; María José Blanco-Teijeiro; María Pardo; Antonio Piñeiro; Manuel Bande
Journal:  Front Genet       Date:  2022-03-31       Impact factor: 4.599

Review 8.  The Genetics and the Genomics of Primary Congenital Glaucoma.

Authors:  Raffaella Cascella; Claudia Strafella; Chiara Germani; Giuseppe Novelli; Federico Ricci; Stefania Zampatti; Emiliano Giardina
Journal:  Biomed Res Int       Date:  2015-09-16       Impact factor: 3.411

9.  Dynamic DNA methylation of matrix metalloproteinase-9 in the development of diabetic retinopathy.

Authors:  Renu A Kowluru; Yang Shan; Manish Mishra
Journal:  Lab Invest       Date:  2016-07-25       Impact factor: 5.662
  9 in total

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